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Association Between Hypovitaminosis D in Elderly Women and Long- and Short-Term Mortality-Results from the Osteoporotic Prospective Risk Assessment Cohort

Buchebner, David LU ; McGuigan, Fiona LU ; Gerdhem, Paul LU ; Ridderstråle, Martin LU and Akesson, Kristina LU (2016) In Journal of the American Geriatrics Society 64(5). p.7-990
Abstract

OBJECTIVES: To investigate the association between low vitamin D levels (<50 nmol/L) and 10-year mortality in women aged 75 and older.

DESIGN: Prospective with 15 years of follow-up.

SETTING: Malmö, Sweden.

PARTICIPANTS: Population-based cohort of 75-year-old women (N = 1,044).

MEASUREMENTS: Serum 25-hydroxyvitamin D (25(OH)D) levels at age 75 (n = 1,011), 80 (n = 642), and 85 (n = 348) were categorized as low (<50 nmol/L), intermediate (50-75 nmol/L) and high (>75 nmol/L) at all ages. Hazard ratios (HRs) for all-cause mortality between ages 75 and 90 were calculated according to 25(OH)D category.

RESULTS: Between ages 80 and 90, all-cause mortality (HR = 1.8, 95% confidence interval (CI) =... (More)

OBJECTIVES: To investigate the association between low vitamin D levels (<50 nmol/L) and 10-year mortality in women aged 75 and older.

DESIGN: Prospective with 15 years of follow-up.

SETTING: Malmö, Sweden.

PARTICIPANTS: Population-based cohort of 75-year-old women (N = 1,044).

MEASUREMENTS: Serum 25-hydroxyvitamin D (25(OH)D) levels at age 75 (n = 1,011), 80 (n = 642), and 85 (n = 348) were categorized as low (<50 nmol/L), intermediate (50-75 nmol/L) and high (>75 nmol/L) at all ages. Hazard ratios (HRs) for all-cause mortality between ages 75 and 90 were calculated according to 25(OH)D category.

RESULTS: Between ages 80 and 90, all-cause mortality (HR = 1.8, 95% confidence interval (CI) = 1.3-2.4, P < .001; adjusted for comorbidities (aHR) = 1.9, 95% CI = 1.4-2.6, P < .001) was significantly higher in women with low 25(OH)D levels than in those with high levels. Osteoporosis had the greatest effect on mortality, but even after excluding women with osteoporotic fracture during the risk of dying associated with low 25(OH)D remained greater (HR = 1.8, 95% CI = 1.2-2.7, P = .002; aHR = 1.7, 95% CI = 1.2-2.5, P = .006).

CONCLUSION: In this observational study of women aged 75 and older, 25(OH)D levels of less than 50 nmol/L were associated with greater all-cause mortality for up to 10 years. This difference was at least partially independent of comorbidities and fracture, indicating that low 25(OH)D not only is an indicator of impaired health, but also plays a role in disease outcome.

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organization
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Contribution to journal
publication status
published
subject
keywords
Aged, Aged, 80 and over, Cause of Death, Comorbidity, Female, Follow-Up Studies, Humans, Osteoporotic Fractures, Prospective Studies, Sweden, Vitamin D Deficiency, Journal Article, Observational Study
in
Journal of the American Geriatrics Society
volume
64
issue
5
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84990248232
  • wos:000377523000007
ISSN
0002-8614
DOI
language
English
LU publication?
yes
id
4cd3d705-4190-487c-8968-4ffc34661789
date added to LUP
2018-01-02 11:48:19
date last changed
2018-05-29 09:22:45
@article{4cd3d705-4190-487c-8968-4ffc34661789,
  abstract     = {<p>OBJECTIVES: To investigate the association between low vitamin D levels (&lt;50 nmol/L) and 10-year mortality in women aged 75 and older.</p><p>DESIGN: Prospective with 15 years of follow-up.</p><p>SETTING: Malmö, Sweden.</p><p>PARTICIPANTS: Population-based cohort of 75-year-old women (N = 1,044).</p><p>MEASUREMENTS: Serum 25-hydroxyvitamin D (25(OH)D) levels at age 75 (n = 1,011), 80 (n = 642), and 85 (n = 348) were categorized as low (&lt;50 nmol/L), intermediate (50-75 nmol/L) and high (&gt;75 nmol/L) at all ages. Hazard ratios (HRs) for all-cause mortality between ages 75 and 90 were calculated according to 25(OH)D category.</p><p>RESULTS: Between ages 80 and 90, all-cause mortality (HR = 1.8, 95% confidence interval (CI) = 1.3-2.4, P &lt; .001; adjusted for comorbidities (aHR) = 1.9, 95% CI = 1.4-2.6, P &lt; .001) was significantly higher in women with low 25(OH)D levels than in those with high levels. Osteoporosis had the greatest effect on mortality, but even after excluding women with osteoporotic fracture during the risk of dying associated with low 25(OH)D remained greater (HR = 1.8, 95% CI = 1.2-2.7, P = .002; aHR = 1.7, 95% CI = 1.2-2.5, P = .006).</p><p>CONCLUSION: In this observational study of women aged 75 and older, 25(OH)D levels of less than 50 nmol/L were associated with greater all-cause mortality for up to 10 years. This difference was at least partially independent of comorbidities and fracture, indicating that low 25(OH)D not only is an indicator of impaired health, but also plays a role in disease outcome.</p>},
  author       = {Buchebner, David and McGuigan, Fiona and Gerdhem, Paul and Ridderstråle, Martin and Akesson, Kristina},
  issn         = {0002-8614},
  keyword      = {Aged,Aged, 80 and over,Cause of Death,Comorbidity,Female,Follow-Up Studies,Humans,Osteoporotic Fractures,Prospective Studies,Sweden,Vitamin D Deficiency,Journal Article,Observational Study},
  language     = {eng},
  number       = {5},
  pages        = {7--990},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of the American Geriatrics Society},
  title        = {Association Between Hypovitaminosis D in Elderly Women and Long- and Short-Term Mortality-Results from the Osteoporotic Prospective Risk Assessment Cohort},
  url          = {http://dx.doi.org/},
  volume       = {64},
  year         = {2016},
}