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A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Christakoudi, Sofia ; Tsilidis, Konstantinos K. ; Dossus, Laure ; Rinaldi, Sabina ; Weiderpass, Elisabete ; Antoniussen, Christian S. ; Dahm, Christina C. ; Tjønneland, Anne ; Mellemkjær, Lene and Katzke, Verena , et al. (2023) In BMC Cancer 23(1).
Abstract

Background: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods: We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective... (More)

Background: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods: We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results: During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961–1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951–1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822–0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835–0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049–1.098), for post-menopausal women (HR = 1.117; 1.085–1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076–1.132), and for ER + PR + subtypes (HR = 1.122; 1.080–1.165; n = 3101), but not for PR- subtypes. Conclusions: In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ABSI, Body shape, Breast cancer, Hip size, Obesity, Waist size
in
BMC Cancer
volume
23
issue
1
article number
562
publisher
BioMed Central (BMC)
external identifiers
  • pmid:37337133
  • scopus:85162196022
ISSN
1471-2407
DOI
10.1186/s12885-023-11056-1
language
English
LU publication?
yes
id
4d170e28-b4e4-4126-8b29-15df64a65d36
date added to LUP
2023-08-29 14:45:03
date last changed
2024-10-05 19:12:22
@article{4d170e28-b4e4-4126-8b29-15df64a65d36,
  abstract     = {{<p>Background: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods: We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results: During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961–1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951–1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822–0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835–0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049–1.098), for post-menopausal women (HR = 1.117; 1.085–1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076–1.132), and for ER + PR + subtypes (HR = 1.122; 1.080–1.165; n = 3101), but not for PR- subtypes. Conclusions: In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.</p>}},
  author       = {{Christakoudi, Sofia and Tsilidis, Konstantinos K. and Dossus, Laure and Rinaldi, Sabina and Weiderpass, Elisabete and Antoniussen, Christian S. and Dahm, Christina C. and Tjønneland, Anne and Mellemkjær, Lene and Katzke, Verena and Kaaks, Rudolf and Schulze, Matthias B. and Masala, Giovanna and Grioni, Sara and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and May, Anne M. and Monninkhof, Evelyn M. and Quirós, J. Ramón and Bonet, Catalina and Sánchez, Maria Jose and Amiano, Pilar and Chirlaque, María Dolores and Guevara, Marcela and Rosendahl, Ann H. and Stocks, Tanja and Perez-Cornago, Aurora and Tin Tin, Sandar and Heath, Alicia K. and Aglago, Elom K. and Peruchet-Noray, Laia and Freisling, Heinz and Riboli, Elio}},
  issn         = {{1471-2407}},
  keywords     = {{ABSI; Body shape; Breast cancer; Hip size; Obesity; Waist size}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Cancer}},
  title        = {{A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort}},
  url          = {{http://dx.doi.org/10.1186/s12885-023-11056-1}},
  doi          = {{10.1186/s12885-023-11056-1}},
  volume       = {{23}},
  year         = {{2023}},
}