Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina LU ; Ekström, Alexander LU ; Noga, Maciej LU ; Omar-Hmeadi, Muhmmad ; Lund, Per-Eric ; Villoutreix, Bruno O ; Krus, Ulrika LU ; Wozniak, Katarzyna LU ; Korsgren, Olle and Renström, Erik LU , et al. (2022) In Proceedings of the National Academy of Sciences of the United States of America 119(24).
Abstract

Significance This project describes the existence of previously unknown non-GPI-anchored CD59 isoforms required for insulin secretion, named CD59-IRIS-1 and CD59-IRIS-2, and finds reduced expression of CD59-IRIS isoforms in human diabetic islets, showing a link between dysregulation of IRIS isoforms and defects in insulin secretion in diabetic patients. These data open a path for future studies into CD59-IRIS expression and function in additional cell types capable of regulated secretion. Identification of additional specific CD59-IRIS binding partners within the cell could provide therapeutic targets for enhancement of insulin secretion in T2D.

Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alternative Splicing, CD59 Antigens/genetics, Diabetes Mellitus/genetics, Humans, Insulin Secretion, Protein Isoforms/genetics
in
Proceedings of the National Academy of Sciences of the United States of America
volume
119
issue
24
article number
e2120083119
pages
10 pages
publisher
National Academy of Sciences
external identifiers
  • scopus:85131345386
  • pmid:35666870
ISSN
1091-6490
DOI
10.1073/pnas.2120083119
language
English
LU publication?
yes
id
4d6470f2-6d77-47f2-b366-aea95a54bc43
date added to LUP
2022-06-20 16:43:47
date last changed
2024-06-12 08:57:54
@article{4d6470f2-6d77-47f2-b366-aea95a54bc43,
  abstract     = {{<p>Significance This project describes the existence of previously unknown non-GPI-anchored CD59 isoforms required for insulin secretion, named CD59-IRIS-1 and CD59-IRIS-2, and finds reduced expression of CD59-IRIS isoforms in human diabetic islets, showing a link between dysregulation of IRIS isoforms and defects in insulin secretion in diabetic patients. These data open a path for future studies into CD59-IRIS expression and function in additional cell types capable of regulated secretion. Identification of additional specific CD59-IRIS binding partners within the cell could provide therapeutic targets for enhancement of insulin secretion in T2D.</p>}},
  author       = {{Golec, Ewelina and Ekström, Alexander and Noga, Maciej and Omar-Hmeadi, Muhmmad and Lund, Per-Eric and Villoutreix, Bruno O and Krus, Ulrika and Wozniak, Katarzyna and Korsgren, Olle and Renström, Erik and Barg, Sebastian and King, Ben C and Blom, Anna M}},
  issn         = {{1091-6490}},
  keywords     = {{Alternative Splicing; CD59 Antigens/genetics; Diabetes Mellitus/genetics; Humans; Insulin Secretion; Protein Isoforms/genetics}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{24}},
  publisher    = {{National Academy of Sciences}},
  series       = {{Proceedings of the National Academy of Sciences of the United States of America}},
  title        = {{Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets}},
  url          = {{http://dx.doi.org/10.1073/pnas.2120083119}},
  doi          = {{10.1073/pnas.2120083119}},
  volume       = {{119}},
  year         = {{2022}},
}