Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction : What Do We Know?
(2021) In Journal of cardiovascular development and disease 8(11). p.1-15- Abstract
Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the... (More)
Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.
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- author
- Bisaccia, Giandomenico ; Ricci, Fabrizio LU ; Recce, Vittoria ; Serio, Antonio ; Iannetti, Giovanni ; Chahal, Anwar A ; Ståhlberg, Marcus ; Khanji, Mohammed Yunus ; Fedorowski, Artur LU and Gallina, Sabina
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of cardiovascular development and disease
- volume
- 8
- issue
- 11
- article number
- 156
- pages
- 1 - 15
- publisher
- MDPI AG
- external identifiers
-
- pmid:34821709
- scopus:85119669555
- ISSN
- 2308-3425
- DOI
- 10.3390/jcdd8110156
- language
- English
- LU publication?
- yes
- id
- 4e3d67c2-dfb3-413b-8007-4e8ead88228e
- date added to LUP
- 2021-11-26 15:39:07
- date last changed
- 2024-09-22 06:37:43
@article{4e3d67c2-dfb3-413b-8007-4e8ead88228e, abstract = {{<p>Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.</p>}}, author = {{Bisaccia, Giandomenico and Ricci, Fabrizio and Recce, Vittoria and Serio, Antonio and Iannetti, Giovanni and Chahal, Anwar A and Ståhlberg, Marcus and Khanji, Mohammed Yunus and Fedorowski, Artur and Gallina, Sabina}}, issn = {{2308-3425}}, language = {{eng}}, number = {{11}}, pages = {{1--15}}, publisher = {{MDPI AG}}, series = {{Journal of cardiovascular development and disease}}, title = {{Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction : What Do We Know?}}, url = {{http://dx.doi.org/10.3390/jcdd8110156}}, doi = {{10.3390/jcdd8110156}}, volume = {{8}}, year = {{2021}}, }