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Association between Serum Cortisol Level and Erectile Function in Healthy Men from the General Population

REZANEZAD, BABAK ; Borgquist, Rasmus LU orcid and Elzanaty, Saad LU (2024) In Archive of Urological Research 8(2). p.023-027
Abstract
Purpose: The aim of the study is to investigate the association between serum levels of cortisol and erectile function in healthy men aged 45-60 years.
Material and methods: The serum level of cortisol was measured. The international index of erectile function-5 items (IIEF-5) was used to assess the erectile function.
Data were gathered on the age of participants, Body Mass Index (BMI), waist circumference, family history of cardiovascular disease, and their habits including alcohol
consumption and smoking. Two subgroups were defi ned, based on the IIEF-5 total score: the normal erectile function group with an IIEF-5 total score ≥ 22 points, and the
erectile dysfunction group with an IIEF-5 total score <22... (More)
Purpose: The aim of the study is to investigate the association between serum levels of cortisol and erectile function in healthy men aged 45-60 years.
Material and methods: The serum level of cortisol was measured. The international index of erectile function-5 items (IIEF-5) was used to assess the erectile function.
Data were gathered on the age of participants, Body Mass Index (BMI), waist circumference, family history of cardiovascular disease, and their habits including alcohol
consumption and smoking. Two subgroups were defi ned, based on the IIEF-5 total score: the normal erectile function group with an IIEF-5 total score ≥ 22 points, and the
erectile dysfunction group with an IIEF-5 total score <22 points.
Results: A positive signifi cant correlation was found between cortisol levels and IIEF-5 total score (r = 0.299, p = 0.003). Cortisol level and IIEF-5 total score showed
negative signifi cant correlations with BMI (r = -0.276, p = 0.004), (r =-0.193, p = 0.041), respectively; and waist circumference (r = -0.319, p = 0.001), (r = -0.283, p = 0.003),
respectively. Men with normal erectile function had signifi cantly higher cortisol levels (377 nmol/L vs. 308 nmol/L, p = <0.001); signifi cantly lower BMI (25 kg/m2 vs. 27 kg/
m2
, p = 0.005), and waist circumference (97 cm vs. 104 cm, p = <0.001) compared to men with erectile dysfunction. In multivariate regression analysis adjusted for the age
of participants, alcohol consumption, smoking, and family history of cardiovascular disease, IIEF-5 total score showed a signifi cant negative association only with waist
circumference (β = -0.194, p = 0.031, 95% CI = -0.370, -0.018).
Conclusions: To our knowledge, this is the fi rst study to demonstrate a signifi cant positive association between serum levels of cortisol and erectile function in healthy
men. This association seems, however, to be affected by variations in body parameters, mainly waist circumference in such men. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archive of Urological Research
volume
8
issue
2
pages
023 - 027
publisher
Peertechz
ISSN
2692-4706
language
English
LU publication?
yes
id
4ea07fa6-6e97-4f4b-bb7e-51c9fe8c679c
alternative location
https://www.organscigroup.us/articles/AUR-8-153.pdf
date added to LUP
2024-10-29 08:33:10
date last changed
2025-04-04 15:04:06
@article{4ea07fa6-6e97-4f4b-bb7e-51c9fe8c679c,
  abstract     = {{Purpose: The aim of the study is to investigate the association between serum levels of cortisol and erectile function in healthy men aged 45-60 years.<br/>Material and methods: The serum level of cortisol was measured. The international index of erectile function-5 items (IIEF-5) was used to assess the erectile function.<br/>Data were gathered on the age of participants, Body Mass Index (BMI), waist circumference, family history of cardiovascular disease, and their habits including alcohol<br/>consumption and smoking. Two subgroups were defi ned, based on the IIEF-5 total score: the normal erectile function group with an IIEF-5 total score ≥ 22 points, and the<br/>erectile dysfunction group with an IIEF-5 total score &lt;22 points.<br/>Results: A positive signifi cant correlation was found between cortisol levels and IIEF-5 total score (r = 0.299, p = 0.003). Cortisol level and IIEF-5 total score showed<br/>negative signifi cant correlations with BMI (r = -0.276, p = 0.004), (r =-0.193, p = 0.041), respectively; and waist circumference (r = -0.319, p = 0.001), (r = -0.283, p = 0.003),<br/>respectively. Men with normal erectile function had signifi cantly higher cortisol levels (377 nmol/L vs. 308 nmol/L, p = &lt;0.001); signifi cantly lower BMI (25 kg/m2 vs. 27 kg/<br/>m2<br/>, p = 0.005), and waist circumference (97 cm vs. 104 cm, p = &lt;0.001) compared to men with erectile dysfunction. In multivariate regression analysis adjusted for the age<br/>of participants, alcohol consumption, smoking, and family history of cardiovascular disease, IIEF-5 total score showed a signifi cant negative association only with waist<br/>circumference (β = -0.194, p = 0.031, 95% CI = -0.370, -0.018).<br/>Conclusions: To our knowledge, this is the fi rst study to demonstrate a signifi cant positive association between serum levels of cortisol and erectile function in healthy<br/>men. This association seems, however, to be affected by variations in body parameters, mainly waist circumference in such men.}},
  author       = {{REZANEZAD, BABAK and Borgquist, Rasmus and Elzanaty, Saad}},
  issn         = {{2692-4706}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{023--027}},
  publisher    = {{Peertechz}},
  series       = {{Archive of Urological Research}},
  title        = {{Association between Serum Cortisol Level and Erectile Function in Healthy Men from the General Population}},
  url          = {{https://www.organscigroup.us/articles/AUR-8-153.pdf}},
  volume       = {{8}},
  year         = {{2024}},
}