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Number of spikes in climbing fibers determines the direction of cerebellar learning.

Rasmussen, Anders LU orcid ; Jirenhed, Dan-Anders LU ; Zucca, Riccardo ; Johansson, Fredrik LU ; Svensson, Pär LU and Hesslow, Germund LU (2013) In The Journal of Neuroscience 33(33). p.13436-13440
Abstract
Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Neuroscience
volume
33
issue
33
pages
13436 - 13440
publisher
Society for Neuroscience
external identifiers
  • wos:000323155700018
  • pmid:23946401
  • scopus:84881503310
  • pmid:23946401
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.1527-13.2013
project
Thinking in Time: Cognition, Communication and Learning
language
English
LU publication?
yes
id
4eb6e75d-8caf-4750-8b16-6d949f8323a1 (old id 4005689)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23946401?dopt=Abstract
date added to LUP
2016-04-01 11:02:16
date last changed
2025-10-14 09:45:10
@article{4eb6e75d-8caf-4750-8b16-6d949f8323a1,
  abstract     = {{Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.}},
  author       = {{Rasmussen, Anders and Jirenhed, Dan-Anders and Zucca, Riccardo and Johansson, Fredrik and Svensson, Pär and Hesslow, Germund}},
  issn         = {{1529-2401}},
  language     = {{eng}},
  number       = {{33}},
  pages        = {{13436--13440}},
  publisher    = {{Society for Neuroscience}},
  series       = {{The Journal of Neuroscience}},
  title        = {{Number of spikes in climbing fibers determines the direction of cerebellar learning.}},
  url          = {{https://lup.lub.lu.se/search/files/2330556/4286411.pdf}},
  doi          = {{10.1523/JNEUROSCI.1527-13.2013}},
  volume       = {{33}},
  year         = {{2013}},
}