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Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

Rohrmann, Sabine; Linseisen, Jakob; Overvad, Kim; Wurtz, Anne Mette Lund; Roswall, Nina; Tjonneland, Anne; Boutron-Ruault, Marie-Christine; Racine, Antoine; Bastide, Nadia and Palli, Domenico, et al. (2015) In International Journal of Cancer 136(5). p.423-431
Abstract
Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and... (More)
Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR=1.36, 95% CI 1.14-1.62; calibrated, per 50 g/day) and processed meat (HR=1.78, 95% CI 1.05-3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction=0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear. What's new? Kidney cancer strikes different populations with different frequency, with developed nations seeing more cases. In this paper, the authors investigate whether certain elements of diet might correlate with increased incidence of renal cell carcinoma. Using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assessed the amount of meat and fish consumed in populations representing a wide range of dietary habits. They then correlated this data with renal cell carcinoma incidence. They found no effect from eating fish; consuming red and processed meats did increase risk in women, but not in men. (Less)
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keywords
renal cell cancer, cohort study, red meat, processed meat
in
International Journal of Cancer
volume
136
issue
5
pages
423 - 431
publisher
John Wiley & Sons
external identifiers
  • wos:000346350500019
  • scopus:84918553894
ISSN
0020-7136
DOI
10.1002/ijc.29236
language
English
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yes
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3143487d-fca0-4fc4-b268-8f7e3dc599b4 (old id 5084956)
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2015-03-02 07:09:42
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@article{3143487d-fca0-4fc4-b268-8f7e3dc599b4,
  abstract     = {Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR=1.36, 95% CI 1.14-1.62; calibrated, per 50 g/day) and processed meat (HR=1.78, 95% CI 1.05-3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction=0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear. What's new? Kidney cancer strikes different populations with different frequency, with developed nations seeing more cases. In this paper, the authors investigate whether certain elements of diet might correlate with increased incidence of renal cell carcinoma. Using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assessed the amount of meat and fish consumed in populations representing a wide range of dietary habits. They then correlated this data with renal cell carcinoma incidence. They found no effect from eating fish; consuming red and processed meats did increase risk in women, but not in men.},
  author       = {Rohrmann, Sabine and Linseisen, Jakob and Overvad, Kim and Wurtz, Anne Mette Lund and Roswall, Nina and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Racine, Antoine and Bastide, Nadia and Palli, Domenico and Agnoli, Claudia and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Weikert, Steffen and Steffen, Annika and Kuehn, Tilman and Li, Kuanrong and Khaw, Kay-Tee and Wareham, Nicholas J. and Bradbury, Kathryn E. and Peppa, Eleni and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. and Hjartaker, Anette and Skeie, Guri and Weiderpass, Elisabete and Jakszyn, Paula and Dorronsoro, Miren and Barricarte, Aurelio and Santiuste de Pablos, Carmen and Molina-Montes, Esther and Alonso de la Torre, Ramon and Ericson, Ulrika and Sonestedt, Emily and Johansson, Mattias and Ljungberg, Borje and Freisling, Heinz and Romieu, Isabelle and Cross, Amanda J. and Vergnaud, Anne-Claire and Riboli, Elio and Boeing, Heiner},
  issn         = {0020-7136},
  keyword      = {renal cell cancer,cohort study,red meat,processed meat},
  language     = {eng},
  number       = {5},
  pages        = {423--431},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.29236},
  volume       = {136},
  year         = {2015},
}