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Cadmium may impair prostate function as measured by Prostate Specific Antigen in semen: a cross-sectional study among European and Inuit men.

Andreucci, Alessandro; Mocevic, Emina; Jönsson, Bo A LU ; Giwercman, Aleksander LU ; Giwercman, Yvonne LU ; Toft, Gunnar; Lundh, Thomas LU ; Bizzaro, Davide; Specht, Ina Olmer and Bonde, Jens Peter (2015) In Reproductive Toxicology 53(Feb 3). p.33-38
Abstract
We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log (ß)= -0.121, 95% Confidence Interval (CI):-0.213; -0.029, P=0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log (ß)=-0.231, 95% CI:-0.363; -0.098, P=0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and... (More)
We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log (ß)= -0.121, 95% Confidence Interval (CI):-0.213; -0.029, P=0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log (ß)=-0.231, 95% CI:-0.363; -0.098, P=0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Reproductive Toxicology
volume
53
issue
Feb 3
pages
33 - 38
publisher
Elsevier
external identifiers
  • pmid:25660730
  • wos:000356318900005
  • scopus:84926482807
ISSN
1873-1708
DOI
10.1016/j.reprotox.2015.01.010
language
English
LU publication?
yes
id
1b3b3484-5353-405a-83b4-01aa25107a53 (old id 5145128)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25660730?dopt=Abstract
date added to LUP
2015-03-05 17:11:01
date last changed
2017-05-21 03:22:18
@article{1b3b3484-5353-405a-83b4-01aa25107a53,
  abstract     = {We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log (ß)= -0.121, 95% Confidence Interval (CI):-0.213; -0.029, P=0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log (ß)=-0.231, 95% CI:-0.363; -0.098, P=0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.},
  author       = {Andreucci, Alessandro and Mocevic, Emina and Jönsson, Bo A and Giwercman, Aleksander and Giwercman, Yvonne and Toft, Gunnar and Lundh, Thomas and Bizzaro, Davide and Specht, Ina Olmer and Bonde, Jens Peter},
  issn         = {1873-1708},
  language     = {eng},
  number       = {Feb 3},
  pages        = {33--38},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Cadmium may impair prostate function as measured by Prostate Specific Antigen in semen: a cross-sectional study among European and Inuit men.},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2015.01.010},
  volume       = {53},
  year         = {2015},
}