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The risk for depression in patients with ankylosing spondylitis: a population-based cohort study

Meesters, Jorit J. L.; Bremander, Ann LU ; Bergman, Stefan LU ; Petersson, Ingemar LU ; Turkiewicz, Aleksandra LU and Englund, Martin LU (2014) In Arthritis Research and Therapy 16(418). p.1-5
Abstract
Introduction: Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a well defined cohort of AS patients to the general population seeking care. Methods: The Skane Healthcare Register comprises healthcare data of each resident in Region Skane, Sweden (population 1.2 million), including ICD-10 diagnoses. Using physician coded consultation data from years 1999 to 2011, we calculated depression consultation rates for all AS patients. We obtained standardized depression-rate ratios by dividing the observed depression rate in AS patients by the expected rate based on the corresponding age-and... (More)
Introduction: Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a well defined cohort of AS patients to the general population seeking care. Methods: The Skane Healthcare Register comprises healthcare data of each resident in Region Skane, Sweden (population 1.2 million), including ICD-10 diagnoses. Using physician coded consultation data from years 1999 to 2011, we calculated depression consultation rates for all AS patients. We obtained standardized depression-rate ratios by dividing the observed depression rate in AS patients by the expected rate based on the corresponding age-and sex-specific rates of depression in the general population seeking care. A ratio > 1 equals a higher rate of depression among AS patients. Results: The AS cohort consisted of 1738 subjects (65% men) with a mean age of 54 years. The reference population consisted of 967,012 subjects. During the 13-year observation period 10% (n = 172) of the AS cohort had a doctor-diagnosed depression compared to 6% (n = 105) to be expected. The standardized estimate of depression-rate ratio was 1.81 (95% confidence interval 1.44 to 2.24) in women men and 1.49 (1.20 to 1.89) in men. Conclusions: The rate of doctor-diagnosed depression is increased about 80% in female and 50% in male AS patients. Future challenges are to timely identify and treat the AS patients who suffer from depression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
16
issue
418
pages
1 - 5
publisher
BioMed Central
external identifiers
  • wos:000349885900003
  • scopus:84910037660
ISSN
1478-6362
DOI
10.1186/s13075-014-0418-z
language
English
LU publication?
yes
id
b6aa1008-319b-423c-a7da-a7a150ecd2f5 (old id 5185962)
date added to LUP
2015-04-01 07:35:25
date last changed
2017-07-09 03:17:21
@article{b6aa1008-319b-423c-a7da-a7a150ecd2f5,
  abstract     = {Introduction: Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a well defined cohort of AS patients to the general population seeking care. Methods: The Skane Healthcare Register comprises healthcare data of each resident in Region Skane, Sweden (population 1.2 million), including ICD-10 diagnoses. Using physician coded consultation data from years 1999 to 2011, we calculated depression consultation rates for all AS patients. We obtained standardized depression-rate ratios by dividing the observed depression rate in AS patients by the expected rate based on the corresponding age-and sex-specific rates of depression in the general population seeking care. A ratio > 1 equals a higher rate of depression among AS patients. Results: The AS cohort consisted of 1738 subjects (65% men) with a mean age of 54 years. The reference population consisted of 967,012 subjects. During the 13-year observation period 10% (n = 172) of the AS cohort had a doctor-diagnosed depression compared to 6% (n = 105) to be expected. The standardized estimate of depression-rate ratio was 1.81 (95% confidence interval 1.44 to 2.24) in women men and 1.49 (1.20 to 1.89) in men. Conclusions: The rate of doctor-diagnosed depression is increased about 80% in female and 50% in male AS patients. Future challenges are to timely identify and treat the AS patients who suffer from depression.},
  author       = {Meesters, Jorit J. L. and Bremander, Ann and Bergman, Stefan and Petersson, Ingemar and Turkiewicz, Aleksandra and Englund, Martin},
  issn         = {1478-6362},
  language     = {eng},
  number       = {418},
  pages        = {1--5},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {The risk for depression in patients with ankylosing spondylitis: a population-based cohort study},
  url          = {http://dx.doi.org/10.1186/s13075-014-0418-z},
  volume       = {16},
  year         = {2014},
}