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Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Bhoo-Pathy, Nirmala; Peeters, Petra H. M.; Uiterwaal, Cuno S. P. M.; Bueno-de-Mesquita, H. Bas; Bulgiba, Awang M.; Bech, Bodil Hammer; Overvad, Kim; Tjonneland, Anne; Olsen, Anja and Clavel-Chapelon, Francoise, et al. (2015) In Breast Cancer Research 17.
Abstract
Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed.... (More)
Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR = 0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; P-trend = 0.029. While there was no significant effect modification by hormone receptor status (P = 0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P = 0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR = 0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (P-trend = 0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR = 0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. Conclusions: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer. (Less)
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Breast Cancer Research
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17
publisher
BioMed Central
external identifiers
  • wos:000351724600001
  • scopus:84924263203
ISSN
1465-5411
DOI
10.1186/s13058-015-0521-3
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English
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6e1212ec-1d7a-427e-8725-198ca829fb19 (old id 5293828)
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2015-05-04 08:33:23
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2017-10-29 03:03:25
@article{6e1212ec-1d7a-427e-8725-198ca829fb19,
  abstract     = {Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR = 0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; P-trend = 0.029. While there was no significant effect modification by hormone receptor status (P = 0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P = 0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR = 0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (P-trend = 0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR = 0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. Conclusions: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.},
  articleno    = {15},
  author       = {Bhoo-Pathy, Nirmala and Peeters, Petra H. M. and Uiterwaal, Cuno S. P. M. and Bueno-de-Mesquita, H. Bas and Bulgiba, Awang M. and Bech, Bodil Hammer and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Clavel-Chapelon, Francoise and Fagherazzi, Guy and Perquier, Florence and Teucher, Birgit and Kaaks, Rudolf and Schuetze, Madlen and Boeing, Heiner and Lagiou, Pagona and Orfanos, Philippos and Trichopoulou, Antonia and Agnoli, Claudia and Mattiello, Amalia and Palli, Domenico and Tumino, Rosario and Sacerdote, Carlotta and van Duijnhoven, Franzel J. B. and Braaten, Tonje and Lund, Eiliv and Skeie, Guri and Redondo, Maria-Luisa and Buckland, Genevieve and Sanchez Perez, Maria Jose and Chirlaque, Maria-Dolores and Ardanaz, Eva and Amiano, Pilar and Wirfält, Elisabet and Wallström, Peter and Johansson, Ingegerd and Nilsson, Lena Maria and Khaw, Kay-Tee and Wareham, Nick and Allen, Naomi E. and Key, Timothy J. and Rinaldi, Sabina and Romieu, Isabelle and Gallo, Valentina and Riboli, Elio and van Gils, Carla H.},
  issn         = {1465-5411},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Breast Cancer Research},
  title        = {Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study},
  url          = {http://dx.doi.org/10.1186/s13058-015-0521-3},
  volume       = {17},
  year         = {2015},
}