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Physical activity and risk of colon and rectal cancers: The European Prospective Investigation into Cancer and Nutrition

Friedenreich, Christine; Norat, Teresa; Steindorf, Karen; Boutron-Ruault, Marie-Christine; Pischon, Tobias; Mazuir, Mathieu; Clavel-Chapelon, Francoise; Linseisen, Jakob; Boeing, Heiner and Bergman, Manuela, et al. (2006) In Cancer Epidemiology Biomarkers & Prevention 15(12). p.2398-2407
Abstract
We investigated several aspects of the role of physical activity in colon and rectal cancer etiology that remain unclear in the European Prospective Investigation into Nutrition and Cancer. This cohort of 413,044 men and women had 1,094 cases of colon and 599 cases of rectal cancer diagnosed during an average of 6.4 years of follow-up. We analyzed baseline data on occupational, household, and recreational activity to examine associations by type of activity, tumor subsite, body mass index (BMI), and energy intake. The multivariate hazard ratio for colon cancer was 0.78 [95% confidence interval (95% CI), 0.59-1.03] among the most active participants when compared with the inactive, with evidence of a dose-response effect (P-trend = 0.04).... (More)
We investigated several aspects of the role of physical activity in colon and rectal cancer etiology that remain unclear in the European Prospective Investigation into Nutrition and Cancer. This cohort of 413,044 men and women had 1,094 cases of colon and 599 cases of rectal cancer diagnosed during an average of 6.4 years of follow-up. We analyzed baseline data on occupational, household, and recreational activity to examine associations by type of activity, tumor subsite, body mass index (BMI), and energy intake. The multivariate hazard ratio for colon cancer was 0.78 [95% confidence interval (95% CI), 0.59-1.03] among the most active participants when compared with the inactive, with evidence of a dose-response effect (P-trend = 0.04). For right-sided colon tumors, the risk was 0.65 (95% CI, 0.43-1.00) in the highest quartile of activity with evidence of a linear trend (P-trend=0.004). Active participants with a BMI under 25 had a risk of 0.63 (95% CI, 0.39-1.01) for colon cancer compared with the inactive. Finally, an interaction between BMI and activity (P-interaction=0.03) was observed for right-sided colon cancers; among moderately active and active participants with a BMI under 25, a risk of 0.38 (95% CI, 0.21-0.68) was found as compared with inactive participants with BMI > 30. No comparable decreased risks were observed for rectal cancer for any type of physical activity for any subgroup analyses or interactions considered. We found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
15
issue
12
pages
2398 - 2407
publisher
American Association for Cancer Research
external identifiers
  • wos:000242984400014
  • scopus:33846020907
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-06-0595
language
English
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52f84319-d5d4-4013-a9a8-989aca847f62 (old id 681875)
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2008-01-03 12:37:27
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@article{52f84319-d5d4-4013-a9a8-989aca847f62,
  abstract     = {We investigated several aspects of the role of physical activity in colon and rectal cancer etiology that remain unclear in the European Prospective Investigation into Nutrition and Cancer. This cohort of 413,044 men and women had 1,094 cases of colon and 599 cases of rectal cancer diagnosed during an average of 6.4 years of follow-up. We analyzed baseline data on occupational, household, and recreational activity to examine associations by type of activity, tumor subsite, body mass index (BMI), and energy intake. The multivariate hazard ratio for colon cancer was 0.78 [95% confidence interval (95% CI), 0.59-1.03] among the most active participants when compared with the inactive, with evidence of a dose-response effect (P-trend = 0.04). For right-sided colon tumors, the risk was 0.65 (95% CI, 0.43-1.00) in the highest quartile of activity with evidence of a linear trend (P-trend=0.004). Active participants with a BMI under 25 had a risk of 0.63 (95% CI, 0.39-1.01) for colon cancer compared with the inactive. Finally, an interaction between BMI and activity (P-interaction=0.03) was observed for right-sided colon cancers; among moderately active and active participants with a BMI under 25, a risk of 0.38 (95% CI, 0.21-0.68) was found as compared with inactive participants with BMI > 30. No comparable decreased risks were observed for rectal cancer for any type of physical activity for any subgroup analyses or interactions considered. We found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer.},
  author       = {Friedenreich, Christine and Norat, Teresa and Steindorf, Karen and Boutron-Ruault, Marie-Christine and Pischon, Tobias and Mazuir, Mathieu and Clavel-Chapelon, Francoise and Linseisen, Jakob and Boeing, Heiner and Bergman, Manuela and Johnsen, Nina Forts and Tjonneland, Anne and Overvad, Kim and Mendez, Michelle and Quiros, J. Ramon and Martinez, Carmen and Dorronsoro, Miren and Navarro, Carmen and Gurrea, Aurelio Barricarte and Bingham, Sheila and Khaw, Kay-Tee and Allen, Naomi and Key, Tim and Trichopoujou, Antonia and Trichopoulos, Dimitrios and Orfanou, Natassa and Krogh, Vittorio and Palli, Domenico and Tumino, Rosario and Panico, Salvatore and Vineis, Paolo and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. and Monninkhof, Evelyn and Berglund, Göran and Manjer, Jonas and Ferrari, Pietro and Slimani, Nadia and Kaaks, Rudolf and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {12},
  pages        = {2398--2407},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Physical activity and risk of colon and rectal cancers: The European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-06-0595},
  volume       = {15},
  year         = {2006},
}