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Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for Idiopathic Scoliosis.

Grauers, A; Wang, J; Einarsdottir, E; Simony, A; Danielsson, A; Åkesson, Kristina LU ; Ohlin, Acke LU ; Halldin, K; Grabowski, P and Tenne, Max LU , et al. (2015) In The Spine Journal
Abstract
Idiopathic Scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies (GWAS) have identified a number of common genetic variants that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to the LBX1 gene being the most replicated finding.
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The Spine Journal
publisher
Elsevier
external identifiers
  • pmid:25987191
  • scopus:84942504402
ISSN
1878-1632
DOI
10.1016/j.spinee.2015.05.013
language
English
LU publication?
yes
id
4a65be88-5e4b-4153-8381-4a8be0cc79b1 (old id 5448857)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25987191?dopt=Abstract
date added to LUP
2015-06-04 22:12:42
date last changed
2017-08-06 04:44:29
@article{4a65be88-5e4b-4153-8381-4a8be0cc79b1,
  abstract     = {Idiopathic Scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies (GWAS) have identified a number of common genetic variants that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to the LBX1 gene being the most replicated finding.},
  author       = {Grauers, A and Wang, J and Einarsdottir, E and Simony, A and Danielsson, A and Åkesson, Kristina and Ohlin, Acke and Halldin, K and Grabowski, P and Tenne, Max and Laivuori, H and Dahlman, I and Andersen, M and Christensen, S B and Karlsson, Magnus and Jiao, H and Kere, J and Gerdhem, Paul},
  issn         = {1878-1632},
  language     = {eng},
  month        = {05},
  publisher    = {Elsevier},
  series       = {The Spine Journal},
  title        = {Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for Idiopathic Scoliosis.},
  url          = {http://dx.doi.org/10.1016/j.spinee.2015.05.013},
  year         = {2015},
}