Aberrant nigral diffusion in Parkinson's disease : A longitudinal diffusion tensor imaging study
(2016) In Movement Disorders 31(7). p.6-1020- Abstract
BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.
METHODS: We have conducted a cross-sectional and longitudinal diffusion tensor imaging study in 18 early stage, treated PD patients and 14 age-matched controls. PD patients were scanned on 2 occasions OFF medication, 19.3 months apart (standard deviation = 3.1 months). Longitudinal change of regional nigral and striatal measures of... (More)
BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.
METHODS: We have conducted a cross-sectional and longitudinal diffusion tensor imaging study in 18 early stage, treated PD patients and 14 age-matched controls. PD patients were scanned on 2 occasions OFF medication, 19.3 months apart (standard deviation = 3.1 months). Longitudinal change of regional nigral and striatal measures of fractional anisotropy and mean diffusivity were calculated using a region-of-interest approach.
RESULTS: Region-of-interest analysis demonstrated that at baseline, PD patients and controls did not differ in regard to diffusion indices in any region assessed. A significant difference of nigral fractional anisotropy and mean diffusivity between controls and PD patients at follow-up was detected and confirmed with longitudinal analysis within PD patients. Alterations in striatal regions were not detected in either group or over time.
CONCLUSION: Our findings indicate that nigral diffusion measure may be a valuable measure of disease progression. In the future, larger longitudinal studies will confirm whether diffusion indices may serve as sensitive and clinically meaningful measures of disease progression in PD. © 2016 International Parkinson and Movement Disorder Society.
(Less)
- author
- Loane, Clare
; Politis, Marios
; Kefalopoulou, Zinovia
; Valle-Guzman, Natalie
; Paul, Gesine
LU
; Widner, Håkan LU ; Foltynie, Thomas ; Barker, Roger A LU and Piccini, Paola
- organization
- publishing date
- 2016-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Movement Disorders
- volume
- 31
- issue
- 7
- pages
- 6 - 1020
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:84977500207
- wos:000379942900017
- pmid:27104232
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.26606
- language
- English
- LU publication?
- yes
- id
- 54730d05-0ab9-4521-8948-3a76eb349154
- date added to LUP
- 2016-11-23 13:08:36
- date last changed
- 2025-01-12 15:43:39
@article{54730d05-0ab9-4521-8948-3a76eb349154, abstract = {{<p>BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.</p><p>METHODS: We have conducted a cross-sectional and longitudinal diffusion tensor imaging study in 18 early stage, treated PD patients and 14 age-matched controls. PD patients were scanned on 2 occasions OFF medication, 19.3 months apart (standard deviation = 3.1 months). Longitudinal change of regional nigral and striatal measures of fractional anisotropy and mean diffusivity were calculated using a region-of-interest approach.</p><p>RESULTS: Region-of-interest analysis demonstrated that at baseline, PD patients and controls did not differ in regard to diffusion indices in any region assessed. A significant difference of nigral fractional anisotropy and mean diffusivity between controls and PD patients at follow-up was detected and confirmed with longitudinal analysis within PD patients. Alterations in striatal regions were not detected in either group or over time.</p><p>CONCLUSION: Our findings indicate that nigral diffusion measure may be a valuable measure of disease progression. In the future, larger longitudinal studies will confirm whether diffusion indices may serve as sensitive and clinically meaningful measures of disease progression in PD. © 2016 International Parkinson and Movement Disorder Society.</p>}}, author = {{Loane, Clare and Politis, Marios and Kefalopoulou, Zinovia and Valle-Guzman, Natalie and Paul, Gesine and Widner, Håkan and Foltynie, Thomas and Barker, Roger A and Piccini, Paola}}, issn = {{0885-3185}}, keywords = {{Journal Article}}, language = {{eng}}, number = {{7}}, pages = {{6--1020}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Movement Disorders}}, title = {{Aberrant nigral diffusion in Parkinson's disease : A longitudinal diffusion tensor imaging study}}, url = {{http://dx.doi.org/10.1002/mds.26606}}, doi = {{10.1002/mds.26606}}, volume = {{31}}, year = {{2016}}, }