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Aberrant nigral diffusion in Parkinson's disease : A longitudinal diffusion tensor imaging study

Loane, Clare ; Politis, Marios ; Kefalopoulou, Zinovia ; Valle-Guzman, Natalie ; Paul, Gesine LU ; Widner, Håkan LU ; Foltynie, Thomas ; Barker, Roger A LU and Piccini, Paola (2016) In Movement Disorders 31(7). p.6-1020
Abstract

BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.

METHODS: We have conducted a cross-sectional and longitudinal diffusion tensor imaging study in 18 early stage, treated PD patients and 14 age-matched controls. PD patients were scanned on 2 occasions OFF medication, 19.3 months apart (standard deviation = 3.1 months). Longitudinal change of regional nigral and striatal measures of... (More)

BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.

METHODS: We have conducted a cross-sectional and longitudinal diffusion tensor imaging study in 18 early stage, treated PD patients and 14 age-matched controls. PD patients were scanned on 2 occasions OFF medication, 19.3 months apart (standard deviation = 3.1 months). Longitudinal change of regional nigral and striatal measures of fractional anisotropy and mean diffusivity were calculated using a region-of-interest approach.

RESULTS: Region-of-interest analysis demonstrated that at baseline, PD patients and controls did not differ in regard to diffusion indices in any region assessed. A significant difference of nigral fractional anisotropy and mean diffusivity between controls and PD patients at follow-up was detected and confirmed with longitudinal analysis within PD patients. Alterations in striatal regions were not detected in either group or over time.

CONCLUSION: Our findings indicate that nigral diffusion measure may be a valuable measure of disease progression. In the future, larger longitudinal studies will confirm whether diffusion indices may serve as sensitive and clinically meaningful measures of disease progression in PD. © 2016 International Parkinson and Movement Disorder Society.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Movement Disorders
volume
31
issue
7
pages
6 - 1020
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:27104232
  • scopus:84977500207
  • wos:000379942900017
ISSN
0885-3185
DOI
10.1002/mds.26606
language
English
LU publication?
yes
id
54730d05-0ab9-4521-8948-3a76eb349154
date added to LUP
2016-11-23 13:08:36
date last changed
2024-05-04 13:34:08
@article{54730d05-0ab9-4521-8948-3a76eb349154,
  abstract     = {{<p>BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.</p><p>METHODS: We have conducted a cross-sectional and longitudinal diffusion tensor imaging study in 18 early stage, treated PD patients and 14 age-matched controls. PD patients were scanned on 2 occasions OFF medication, 19.3 months apart (standard deviation = 3.1 months). Longitudinal change of regional nigral and striatal measures of fractional anisotropy and mean diffusivity were calculated using a region-of-interest approach.</p><p>RESULTS: Region-of-interest analysis demonstrated that at baseline, PD patients and controls did not differ in regard to diffusion indices in any region assessed. A significant difference of nigral fractional anisotropy and mean diffusivity between controls and PD patients at follow-up was detected and confirmed with longitudinal analysis within PD patients. Alterations in striatal regions were not detected in either group or over time.</p><p>CONCLUSION: Our findings indicate that nigral diffusion measure may be a valuable measure of disease progression. In the future, larger longitudinal studies will confirm whether diffusion indices may serve as sensitive and clinically meaningful measures of disease progression in PD. © 2016 International Parkinson and Movement Disorder Society.</p>}},
  author       = {{Loane, Clare and Politis, Marios and Kefalopoulou, Zinovia and Valle-Guzman, Natalie and Paul, Gesine and Widner, Håkan and Foltynie, Thomas and Barker, Roger A and Piccini, Paola}},
  issn         = {{0885-3185}},
  keywords     = {{Journal Article}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{6--1020}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Movement Disorders}},
  title        = {{Aberrant nigral diffusion in Parkinson's disease : A longitudinal diffusion tensor imaging study}},
  url          = {{http://dx.doi.org/10.1002/mds.26606}},
  doi          = {{10.1002/mds.26606}},
  volume       = {{31}},
  year         = {{2016}},
}