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TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Russ, Kaspar LU ; Teku, Gabriel LU ; Bousset, Luc ; Redeker, Virginie ; Piel, Sara LU ; Savchenko, Ekaterina LU ; Pomeshchik, Yuriy LU ; Savistchenko, Jimmy ; Stummann, Tina C. and Azevedo, Carla LU , et al. (2021) In Cell Reports 34(12).
Abstract

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

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@article{55dd3dcd-ba93-4cd8-bbbe-ca26cd090795,
  abstract     = {<p>Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.</p>},
  author       = {Russ, Kaspar and Teku, Gabriel and Bousset, Luc and Redeker, Virginie and Piel, Sara and Savchenko, Ekaterina and Pomeshchik, Yuriy and Savistchenko, Jimmy and Stummann, Tina C. and Azevedo, Carla and Collin, Anna and Goldwurm, Stefano and Fog, Karina and Elmer, Eskil and Vihinen, Mauno and Melki, Ronald and Roybon, Laurent},
  issn         = {2211-1247},
  language     = {eng},
  number       = {12},
  publisher    = {Cell Press},
  series       = {Cell Reports},
  title        = {TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration},
  url          = {http://dx.doi.org/10.1016/j.celrep.2021.108895},
  doi          = {10.1016/j.celrep.2021.108895},
  volume       = {34},
  year         = {2021},
}