TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration
(2021) In Cell Reports 34(12).- Abstract
Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/55dd3dcd-ba93-4cd8-bbbe-ca26cd090795
- author
- organization
-
- IPSC Laboratory for CNS Disease Modeling (research group)
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- The genetics of soft tissue tumors (research group)
- Mitochondrial Medicine (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Division of Clinical Genetics
- Protein Bioinformatics (research group)
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alpha-synuclein, astrocytes, HLA genes, iPSC, Parkinson's disease, reactivity
- in
- Cell Reports
- volume
- 34
- issue
- 12
- article number
- 108895
- publisher
- Cell Press
- external identifiers
-
- scopus:85103092287
- pmid:33761362
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2021.108895
- language
- English
- LU publication?
- yes
- id
- 55dd3dcd-ba93-4cd8-bbbe-ca26cd090795
- date added to LUP
- 2021-04-07 14:02:33
- date last changed
- 2025-02-09 09:34:20
@article{55dd3dcd-ba93-4cd8-bbbe-ca26cd090795, abstract = {{<p>Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.</p>}}, author = {{Russ, Kaspar and Teku, Gabriel and Bousset, Luc and Redeker, Virginie and Piel, Sara and Savchenko, Ekaterina and Pomeshchik, Yuriy and Savistchenko, Jimmy and Stummann, Tina C. and Azevedo, Carla and Collin, Anna and Goldwurm, Stefano and Fog, Karina and Elmer, Eskil and Vihinen, Mauno and Melki, Ronald and Roybon, Laurent}}, issn = {{2211-1247}}, keywords = {{alpha-synuclein; astrocytes; HLA genes; iPSC; Parkinson's disease; reactivity}}, language = {{eng}}, number = {{12}}, publisher = {{Cell Press}}, series = {{Cell Reports}}, title = {{TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration}}, url = {{http://dx.doi.org/10.1016/j.celrep.2021.108895}}, doi = {{10.1016/j.celrep.2021.108895}}, volume = {{34}}, year = {{2021}}, }