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TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Russ, Kaspar LU ; Teku, Gabriel LU ; Bousset, Luc ; Redeker, Virginie ; Piel, Sara LU orcid ; Savchenko, Ekaterina LU ; Pomeshchik, Yuriy LU orcid ; Savistchenko, Jimmy ; Stummann, Tina C. and Azevedo, Carla LU , et al. (2021) In Cell Reports 34(12).
Abstract

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha-synuclein, astrocytes, HLA genes, iPSC, Parkinson's disease, reactivity
in
Cell Reports
volume
34
issue
12
article number
108895
publisher
Cell Press
external identifiers
  • pmid:33761362
  • scopus:85103092287
ISSN
2211-1247
DOI
10.1016/j.celrep.2021.108895
language
English
LU publication?
yes
id
55dd3dcd-ba93-4cd8-bbbe-ca26cd090795
date added to LUP
2021-04-07 14:02:33
date last changed
2024-04-20 05:21:58
@article{55dd3dcd-ba93-4cd8-bbbe-ca26cd090795,
  abstract     = {{<p>Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.</p>}},
  author       = {{Russ, Kaspar and Teku, Gabriel and Bousset, Luc and Redeker, Virginie and Piel, Sara and Savchenko, Ekaterina and Pomeshchik, Yuriy and Savistchenko, Jimmy and Stummann, Tina C. and Azevedo, Carla and Collin, Anna and Goldwurm, Stefano and Fog, Karina and Elmer, Eskil and Vihinen, Mauno and Melki, Ronald and Roybon, Laurent}},
  issn         = {{2211-1247}},
  keywords     = {{alpha-synuclein; astrocytes; HLA genes; iPSC; Parkinson's disease; reactivity}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{Cell Press}},
  series       = {{Cell Reports}},
  title        = {{TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration}},
  url          = {{http://dx.doi.org/10.1016/j.celrep.2021.108895}},
  doi          = {{10.1016/j.celrep.2021.108895}},
  volume       = {{34}},
  year         = {{2021}},
}