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The role of phylogenetics in discerning hiv-1 mixing among vulnerable populations and geographic regions in sub-saharan africa : A systematic review

Nduva, George M. LU ; Nazziwa, Jamirah LU orcid ; Hassan, Amin S. LU ; Sanders, Eduard J. and Esbjörnsson, Joakim LU orcid (2021) In Viruses 13(6).
Abstract

To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1... (More)

To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1 transmission dynamics within and between risk groups and geographic locations in sSA (published 1995–2021). We describe HIV-1 transmission from both a geographic and a risk group perspective in sSA. Finally, we discuss the challenges facing phylogenetic inference in mixed epidemics in sSA and offer our perspectives and potential solutions to the identified challenges.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HIV-1, Mixed epidemics, Phylogenetics, Sub-Saharan Africa, Transmission dynamics
in
Viruses
volume
13
issue
6
article number
1174
publisher
MDPI AG
external identifiers
  • scopus:85108976084
  • pmid:34205246
ISSN
1999-4915
DOI
10.3390/v13061174
language
English
LU publication?
yes
id
567bdd9b-162c-44a3-bf57-9364abfa410d
date added to LUP
2021-08-20 10:24:26
date last changed
2024-04-20 10:49:06
@article{567bdd9b-162c-44a3-bf57-9364abfa410d,
  abstract     = {{<p>To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1 transmission dynamics within and between risk groups and geographic locations in sSA (published 1995–2021). We describe HIV-1 transmission from both a geographic and a risk group perspective in sSA. Finally, we discuss the challenges facing phylogenetic inference in mixed epidemics in sSA and offer our perspectives and potential solutions to the identified challenges.</p>}},
  author       = {{Nduva, George M. and Nazziwa, Jamirah and Hassan, Amin S. and Sanders, Eduard J. and Esbjörnsson, Joakim}},
  issn         = {{1999-4915}},
  keywords     = {{HIV-1; Mixed epidemics; Phylogenetics; Sub-Saharan Africa; Transmission dynamics}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{MDPI AG}},
  series       = {{Viruses}},
  title        = {{The role of phylogenetics in discerning hiv-1 mixing among vulnerable populations and geographic regions in sub-saharan africa : A systematic review}},
  url          = {{http://dx.doi.org/10.3390/v13061174}},
  doi          = {{10.3390/v13061174}},
  volume       = {{13}},
  year         = {{2021}},
}