Advanced

Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma : Findings from two prospective cohorts

, ; Berger, Eloise; Delpierre, Cyrille; Hosnijeh, Fatemeh Saberi; Kelly-Irving, Michelle; Portengen, Lutzen; Bergdahl, Ingvar A. LU ; Johansson, Ann Sofie LU ; Krogh, Vittorio and Palli, Domenico, et al. (2018) In Scientific Reports 8(1).
Abstract

Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and... (More)

Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
8
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85050189913
ISSN
2045-2322
DOI
10.1038/s41598-018-29041-1
language
English
LU publication?
yes
id
58f1491c-383d-45e8-8e62-3f456e8a4760
date added to LUP
2018-08-15 14:16:47
date last changed
2019-04-21 05:16:09
@article{58f1491c-383d-45e8-8e62-3f456e8a4760,
  abstract     = {<p>Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.</p>},
  articleno    = {10805},
  author       = {,  and Berger, Eloise and Delpierre, Cyrille and Hosnijeh, Fatemeh Saberi and Kelly-Irving, Michelle and Portengen, Lutzen and Bergdahl, Ingvar A. and Johansson, Ann Sofie and Krogh, Vittorio and Palli, Domenico and Panico, Salvatore and Sacerdote, Carlotta and Tumino, Rosario and Kyrtopoulos, Soterios A. and Vineis, Paolo and Chadeau-Hyam, Marc and Vermeulen, Roel and Castagné, Raphaële and Melin, Beatrice and Lenner, Per and Bendinelli, Benedetta and Botsivali, Maria and Chatziioannou, Aristotelis and Valavanis, Ioannis and Bodinier, Barbara and Garrido-Manriquez, Javiera and Athersuch, Toby J. and Liquet, Benoît and Lokhorst, Henk and Georgiadis, Panagiotis and Kleinjans, Jos C.S. and De Kok, Theo M.C.M. and Keun, Hector C. and Kelly, Rachel and Hallmans, Goran and Stephanou, Euripides G. and Myridakis, Antonis and Kogevinas, Manolis and Fazzo, Lucia and De Santis, Marco and Comba, Pietro and Kiviranta, Hannu and Rantakokko, Panu and Airaksinen, Riikka and Ruokojarvi, Paivi and Gilthorpe, Mark and Fleming, Sarah and Fleming, Thomas and Tu, Yu Kang and Lundh, Thomas and Chien, Kuo Liong},
  issn         = {2045-2322},
  language     = {eng},
  month        = {07},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma : Findings from two prospective cohorts},
  url          = {http://dx.doi.org/10.1038/s41598-018-29041-1},
  volume       = {8},
  year         = {2018},
}