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Nerve regeneration across an extended gap : a neurobiological view of nerve repair and the possible involvement of neuronotrophic factors

Lundborg, G LU ; Dahlin, L B LU ; Danielsen, N LU ; Hansson, H A; Johannesson, A; Longo, F M and Varon, S (1982) In The Journal of hand surgery 7(6). p.7-580
Abstract

We have compared the anatomic and functional regeneration of a transected sciatic nerve following regrowth from its proximal stump through either preformed empty mesothelial chambers or autologous nerve grafts bridging a 10 mm gap. Within the mesothelial chambers an organized multifascicular nerve trunk forms between the proximal and distal stumps. After 3 months, distal segment cross sections from the mesothelial chamber and nerve graft groups did not differ with respect to axonal density or distribution of axonal diameters. Mean conduction velocities across the gaps were also similar, although the nerve graft group had a wider distribution of velocities. Little or no regeneration was evident when the gap between the nerve stumps was... (More)

We have compared the anatomic and functional regeneration of a transected sciatic nerve following regrowth from its proximal stump through either preformed empty mesothelial chambers or autologous nerve grafts bridging a 10 mm gap. Within the mesothelial chambers an organized multifascicular nerve trunk forms between the proximal and distal stumps. After 3 months, distal segment cross sections from the mesothelial chamber and nerve graft groups did not differ with respect to axonal density or distribution of axonal diameters. Mean conduction velocities across the gaps were also similar, although the nerve graft group had a wider distribution of velocities. Little or no regeneration was evident when the gap between the nerve stumps was left empty. These results suggest that if the regrowing proximal stump is in an appropriate environment, it can form a well organized and oriented nerve trunk. In the mesothelial chambers, the regenerating nerve is surrounded by a loose cellular stroma and a small amount of interstitial fluid, which was found to contain trophic activity for cultured rodent sensory neurons. Such factors may also support nerve regeneration in vivo.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Axons, Nerve Regeneration, Neural Conduction, Neural Pathways, Rats, Rats, Inbred Strains, Sciatic Nerve, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
in
The Journal of hand surgery
volume
7
issue
6
pages
7 - 580
publisher
Elsevier
external identifiers
  • scopus:0020420119
ISSN
0363-5023
DOI
10.1016/S0363-5023(82)80107-X
language
English
LU publication?
no
id
5a08785a-abbd-47b8-bb0b-298303f0826f
date added to LUP
2017-10-13 13:46:53
date last changed
2017-11-06 10:07:12
@article{5a08785a-abbd-47b8-bb0b-298303f0826f,
  abstract     = {<p>We have compared the anatomic and functional regeneration of a transected sciatic nerve following regrowth from its proximal stump through either preformed empty mesothelial chambers or autologous nerve grafts bridging a 10 mm gap. Within the mesothelial chambers an organized multifascicular nerve trunk forms between the proximal and distal stumps. After 3 months, distal segment cross sections from the mesothelial chamber and nerve graft groups did not differ with respect to axonal density or distribution of axonal diameters. Mean conduction velocities across the gaps were also similar, although the nerve graft group had a wider distribution of velocities. Little or no regeneration was evident when the gap between the nerve stumps was left empty. These results suggest that if the regrowing proximal stump is in an appropriate environment, it can form a well organized and oriented nerve trunk. In the mesothelial chambers, the regenerating nerve is surrounded by a loose cellular stroma and a small amount of interstitial fluid, which was found to contain trophic activity for cultured rodent sensory neurons. Such factors may also support nerve regeneration in vivo.</p>},
  author       = {Lundborg, G and Dahlin, L B and Danielsen, N and Hansson, H A and Johannesson, A and Longo, F M and Varon, S},
  issn         = {0363-5023},
  keyword      = {Animals,Axons,Nerve Regeneration,Neural Conduction,Neural Pathways,Rats,Rats, Inbred Strains,Sciatic Nerve,Journal Article,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.},
  language     = {eng},
  number       = {6},
  pages        = {7--580},
  publisher    = {Elsevier},
  series       = {The Journal of hand surgery},
  title        = {Nerve regeneration across an extended gap : a neurobiological view of nerve repair and the possible involvement of neuronotrophic factors},
  url          = {http://dx.doi.org/10.1016/S0363-5023(82)80107-X},
  volume       = {7},
  year         = {1982},
}