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Peripheral nerve regeneration in Gore-tex chambers

Danielsen, N LU ; Williams, L R ; Dahlin, L B LU orcid ; Varon, S and Lundborg, G LU (1988) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 22(3). p.10-207
Abstract

Gore-tex chambers were used to bridge a 6 mm gap between the proximal and distal nerve stumps of a rat sciatic nerve. The wall structure of these chambers is characterized by "nodes" interconnected by smaller fibrils. Chambers with internodal distances of 5, 10 and 30 microns were used. Some 30 microns chambers were coated from the outside with Gore-tex (0.2 micron internodal distance) and others were coated from the inside. Regeneration after 12 weeks, as evidenced by muscle action potential recordings and light microscopy, was successful regardless of what type of chamber had been used. The organization of the nerve structure varied among different chamber types. A well organized coaxial nerve structure with myelinated axons was... (More)

Gore-tex chambers were used to bridge a 6 mm gap between the proximal and distal nerve stumps of a rat sciatic nerve. The wall structure of these chambers is characterized by "nodes" interconnected by smaller fibrils. Chambers with internodal distances of 5, 10 and 30 microns were used. Some 30 microns chambers were coated from the outside with Gore-tex (0.2 micron internodal distance) and others were coated from the inside. Regeneration after 12 weeks, as evidenced by muscle action potential recordings and light microscopy, was successful regardless of what type of chamber had been used. The organization of the nerve structure varied among different chamber types. A well organized coaxial nerve structure with myelinated axons was observed if inner-coated chambers were used. In chambers that were not coated or in outer-coated chambers tissue completely filled the chambers, and myelinated axons were arranged in mini-fascicles surrounded by loose connective tissue.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Axons, Diffusion Chambers, Culture, Female, Muscles, Nerve Fibers, Nerve Regeneration, Peripheral Nerves, Polytetrafluoroethylene, Rats, Rats, Inbred Strains, Sciatic Nerve, Journal Article, Research Support, Non-U.S. Gov't
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
volume
22
issue
3
pages
10 - 207
publisher
Taylor & Francis
external identifiers
  • pmid:3252448
  • scopus:0024270542
ISSN
0284-4311
language
English
LU publication?
yes
id
5b2ebbaf-3410-40cf-aebc-8abd9b3d56b1
date added to LUP
2017-10-13 13:45:40
date last changed
2024-01-14 07:23:06
@article{5b2ebbaf-3410-40cf-aebc-8abd9b3d56b1,
  abstract     = {{<p>Gore-tex chambers were used to bridge a 6 mm gap between the proximal and distal nerve stumps of a rat sciatic nerve. The wall structure of these chambers is characterized by "nodes" interconnected by smaller fibrils. Chambers with internodal distances of 5, 10 and 30 microns were used. Some 30 microns chambers were coated from the outside with Gore-tex (0.2 micron internodal distance) and others were coated from the inside. Regeneration after 12 weeks, as evidenced by muscle action potential recordings and light microscopy, was successful regardless of what type of chamber had been used. The organization of the nerve structure varied among different chamber types. A well organized coaxial nerve structure with myelinated axons was observed if inner-coated chambers were used. In chambers that were not coated or in outer-coated chambers tissue completely filled the chambers, and myelinated axons were arranged in mini-fascicles surrounded by loose connective tissue.</p>}},
  author       = {{Danielsen, N and Williams, L R and Dahlin, L B and Varon, S and Lundborg, G}},
  issn         = {{0284-4311}},
  keywords     = {{Animals; Axons; Diffusion Chambers, Culture; Female; Muscles; Nerve Fibers; Nerve Regeneration; Peripheral Nerves; Polytetrafluoroethylene; Rats; Rats, Inbred Strains; Sciatic Nerve; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{10--207}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery}},
  title        = {{Peripheral nerve regeneration in Gore-tex chambers}},
  volume       = {{22}},
  year         = {{1988}},
}