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Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome

Holm, Johan LU ; Hillarp, Andreas LU ; Zöller, Bengt LU orcid ; Erhardt, Leif RW LU ; Berntorp, Erik LU and Dahlbäck, Björn LU (1999) In Thrombosis and Haemostasis 81(6). p.857-860
Abstract
Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The... (More)
Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Activated Protein C Resistance, Acute Disease, Aged, Alleles, Coronary Disease, Factor V, Female, Humans, Male, Middle Aged, Mutation, Polymorphism, Genetic, Prevalence, Prognosis, Risk Factors, Journal Article, Research Support, Non-U.S. Gov't
in
Thrombosis and Haemostasis
volume
81
issue
6
pages
4 pages
publisher
Schattauer GmbH
external identifiers
  • pmid:10404756
  • scopus:0033143554
  • pmid:10404756
ISSN
0340-6245
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Clinical Chemistry, Malmö (013016000), Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)
id
5b4de8b9-a9fd-4478-81a7-cc51163141a3 (old id 1114915)
date added to LUP
2016-04-01 16:38:49
date last changed
2022-01-28 21:06:50
@article{5b4de8b9-a9fd-4478-81a7-cc51163141a3,
  abstract     = {{Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.}},
  author       = {{Holm, Johan and Hillarp, Andreas and Zöller, Bengt and Erhardt, Leif RW and Berntorp, Erik and Dahlbäck, Björn}},
  issn         = {{0340-6245}},
  keywords     = {{Activated Protein C Resistance; Acute Disease; Aged; Alleles; Coronary Disease; Factor V; Female; Humans; Male; Middle Aged; Mutation; Polymorphism, Genetic; Prevalence; Prognosis; Risk Factors; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{857--860}},
  publisher    = {{Schattauer GmbH}},
  series       = {{Thrombosis and Haemostasis}},
  title        = {{Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome}},
  volume       = {{81}},
  year         = {{1999}},
}