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Adipose cell size : Importance in health and disease

Stenkula, Karin G. LU and Erlanson-Albertsson, Charlotte LU (2018) In American Journal of Physiology - Regulatory Integrative and Comparative Physiology 315(2). p.284-295
Abstract

Adipose tissue is necessary to harbor energy. To handle excess energy, adipose tissue expands by increasing adipocyte size (hypertrophy) and number (hyperplasia). Here, we have summarized the different experimental techniques used to study adipocyte cell size and describe adipocyte size in relation to insulin resistance, type 2 diabetes, and diet interventions. Hypertrophic adipocytes have an impaired cellular function, and inherent mechanisms restrict their expansion to protect against cell breakage and subsequent inflammation. Reduction of large fat cells by diet restriction, physical activity, or bariatric surgery therefore is necessary to improve cellular function and health. Small fat cells may also be dysfunctional and unable to... (More)

Adipose tissue is necessary to harbor energy. To handle excess energy, adipose tissue expands by increasing adipocyte size (hypertrophy) and number (hyperplasia). Here, we have summarized the different experimental techniques used to study adipocyte cell size and describe adipocyte size in relation to insulin resistance, type 2 diabetes, and diet interventions. Hypertrophic adipocytes have an impaired cellular function, and inherent mechanisms restrict their expansion to protect against cell breakage and subsequent inflammation. Reduction of large fat cells by diet restriction, physical activity, or bariatric surgery therefore is necessary to improve cellular function and health. Small fat cells may also be dysfunctional and unable to expand. The distribution and function of the entire cell size range of fat cells, from small to very large fat cells, are an important but understudied aspect of adipose tissue biology. To prevent dysmetabolism, therapeutic strategies to expand small fat cells, recruit new fat cells, and reduce large fat cells are needed.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipocytes, Cell size distribution, Diet, Insulin, Obesity
in
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
volume
315
issue
2
pages
284 - 295
publisher
American Physiological Society
external identifiers
  • scopus:85052086964
ISSN
0363-6119
DOI
10.1152/ajpregu.00257.2017
language
English
LU publication?
yes
id
5f611ae0-9e22-44ff-8f7c-c2d46038daad
date added to LUP
2018-09-26 14:42:02
date last changed
2019-08-14 04:23:11
@article{5f611ae0-9e22-44ff-8f7c-c2d46038daad,
  abstract     = {<p>Adipose tissue is necessary to harbor energy. To handle excess energy, adipose tissue expands by increasing adipocyte size (hypertrophy) and number (hyperplasia). Here, we have summarized the different experimental techniques used to study adipocyte cell size and describe adipocyte size in relation to insulin resistance, type 2 diabetes, and diet interventions. Hypertrophic adipocytes have an impaired cellular function, and inherent mechanisms restrict their expansion to protect against cell breakage and subsequent inflammation. Reduction of large fat cells by diet restriction, physical activity, or bariatric surgery therefore is necessary to improve cellular function and health. Small fat cells may also be dysfunctional and unable to expand. The distribution and function of the entire cell size range of fat cells, from small to very large fat cells, are an important but understudied aspect of adipose tissue biology. To prevent dysmetabolism, therapeutic strategies to expand small fat cells, recruit new fat cells, and reduce large fat cells are needed.</p>},
  author       = {Stenkula, Karin G. and Erlanson-Albertsson, Charlotte},
  issn         = {0363-6119},
  keyword      = {Adipocytes,Cell size distribution,Diet,Insulin,Obesity},
  language     = {eng},
  month        = {08},
  number       = {2},
  pages        = {284--295},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology - Regulatory Integrative and Comparative Physiology},
  title        = {Adipose cell size : Importance in health and disease},
  url          = {http://dx.doi.org/10.1152/ajpregu.00257.2017},
  volume       = {315},
  year         = {2018},
}