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Tissue temperature monitoring during interstitial photodynamic therapy

Svensson, Jenny LU ; Johansson, Ann LU ; Svanberg, Katarina LU and Andersson-Engels, Stefan LU (2005) Thermal Treatment of Tissue: Energy Delivery and Assessment III In Proceedings of the SPIE - The International Society for Optical Engineering 5698(1). p.126-136
Abstract
During δ-aminolevulinic acid (ALA) based Interstitial Photodynamic Therapy (IPDT) a high light fluence rate is present close to the source fibers. This might induce an unintentional tissue temperature increase of importance for the treatment outcome. In a previous study, we have observed, that the absorption in the tissue increases during the treatment. A system to measure the local tissue temperature at the source fibers during IPDT on tissue phantoms is presented. The temperature was measured by acquiring the fluorescence from small Cr<sup>3+</sup>-doped crystals attached to the tip of the illumination fiber used in an IPDT-system. The fluorescence of the Alexandrite crystal used is temperature dependent. A ratio of the... (More)
During δ-aminolevulinic acid (ALA) based Interstitial Photodynamic Therapy (IPDT) a high light fluence rate is present close to the source fibers. This might induce an unintentional tissue temperature increase of importance for the treatment outcome. In a previous study, we have observed, that the absorption in the tissue increases during the treatment. A system to measure the local tissue temperature at the source fibers during IPDT on tissue phantoms is presented. The temperature was measured by acquiring the fluorescence from small Cr<sup>3+</sup>-doped crystals attached to the tip of the illumination fiber used in an IPDT-system. The fluorescence of the Alexandrite crystal used is temperature dependent. A ratio of the intensity of the fluorescence was formed between two different wavelength bands in the red region. The system was calibrated by immersing the fibers in an Intralipid solution placed in a temperature controlled oven. Measurements were then performed by placing the fibers interstitially in a pork chop as a tissue phantom. Measurements were also performed superficially on skin on a volunteer. A treatment was conducted for 10 minutes, and the fluorescence was measured each minute during the illumination. The fluorescence yielded the temperature at the fiber tip through the calibration curve. The measurements indicate a temperature increase of a few degrees during the simulated treatment (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Alexandrite crystal, illumination fiber, Cr<sup>3+</sup>-doped crystal, fluorescence, tissue phantom, light fluence rate, δ-aminolevulinic acid, tissue temperature monitoring, interstitial photodynamic therapy, temperature-dependent fluorescence, skin, intralipid solution
in
Proceedings of the SPIE - The International Society for Optical Engineering
volume
5698
issue
1
pages
126 - 136
publisher
SPIE
conference name
Thermal Treatment of Tissue: Energy Delivery and Assessment III
external identifiers
  • wos:000229738000013
  • scopus:23244432143
ISSN
0277-786X
1996-756X
DOI
10.1117/12.588485
language
English
LU publication?
yes
id
618fe85e-b29b-4872-8dbd-8b1ca77624a2 (old id 615744)
date added to LUP
2007-11-25 17:10:46
date last changed
2017-01-01 04:39:39
@inproceedings{618fe85e-b29b-4872-8dbd-8b1ca77624a2,
  abstract     = {During δ-aminolevulinic acid (ALA) based Interstitial Photodynamic Therapy (IPDT) a high light fluence rate is present close to the source fibers. This might induce an unintentional tissue temperature increase of importance for the treatment outcome. In a previous study, we have observed, that the absorption in the tissue increases during the treatment. A system to measure the local tissue temperature at the source fibers during IPDT on tissue phantoms is presented. The temperature was measured by acquiring the fluorescence from small Cr&lt;sup&gt;3+&lt;/sup&gt;-doped crystals attached to the tip of the illumination fiber used in an IPDT-system. The fluorescence of the Alexandrite crystal used is temperature dependent. A ratio of the intensity of the fluorescence was formed between two different wavelength bands in the red region. The system was calibrated by immersing the fibers in an Intralipid solution placed in a temperature controlled oven. Measurements were then performed by placing the fibers interstitially in a pork chop as a tissue phantom. Measurements were also performed superficially on skin on a volunteer. A treatment was conducted for 10 minutes, and the fluorescence was measured each minute during the illumination. The fluorescence yielded the temperature at the fiber tip through the calibration curve. The measurements indicate a temperature increase of a few degrees during the simulated treatment},
  author       = {Svensson, Jenny and Johansson, Ann and Svanberg, Katarina and Andersson-Engels, Stefan},
  booktitle    = {Proceedings of the SPIE - The International Society for Optical Engineering},
  issn         = {0277-786X},
  keyword      = {Alexandrite crystal,illumination fiber,Cr<sup>3+</sup>-doped crystal,fluorescence,tissue phantom,light fluence rate,δ-aminolevulinic acid,tissue temperature monitoring,interstitial photodynamic therapy,temperature-dependent fluorescence,skin,intralipid solution},
  language     = {eng},
  number       = {1},
  pages        = {126--136},
  publisher    = {SPIE},
  title        = {Tissue temperature monitoring during interstitial photodynamic therapy},
  url          = {http://dx.doi.org/10.1117/12.588485},
  volume       = {5698},
  year         = {2005},
}