Lung function is associated with tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in school-aged children
(2021) In Respiratory Medicine 176.- Abstract
Background: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with inflammatory and apoptotic properties. A complex relationship exists between TRAIL and the lung where both elevated TRAIL and TRAIL deficiency are associated with lung impairment. In neonatal mice, TRAIL is thought to translate respiratory infections into chronic lung disease but the association between TRAIL and lung function in childhood has not been assessed. Aim: To assess the cross-sectional relationship between TRAIL levels and lung function in school-aged children. Methods: The study cohort consisted of 170 school-aged children attending four schools in Malmö, Sweden. Lung volumes, impulse oscillometry (IOS) and serum TRAIL were... (More)
Background: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with inflammatory and apoptotic properties. A complex relationship exists between TRAIL and the lung where both elevated TRAIL and TRAIL deficiency are associated with lung impairment. In neonatal mice, TRAIL is thought to translate respiratory infections into chronic lung disease but the association between TRAIL and lung function in childhood has not been assessed. Aim: To assess the cross-sectional relationship between TRAIL levels and lung function in school-aged children. Methods: The study cohort consisted of 170 school-aged children attending four schools in Malmö, Sweden. Lung volumes, impulse oscillometry (IOS) and serum TRAIL were measured for all children. Linear regression was used to assess changes in lung function per 1-SD increase in TRAIL. General linear models were used to assess mean lung function by tertiles (T) of TRAIL. Results: Mean age was 9.9 years (±0.6). A 1-SD increase in TRAIL was associated with lower values of FEV1 and FEV1/VC (change in FEV1 (L) and FEV1/VC ratio: −0.047, p-value 0.002, and −0.011, p-value 0.020, respectively) and higher values of lung resistance (change in R5 and R20 (kPa/(L/s)): 0.035, p-value <0.001 and 0.027, p-value 0.004, respectively). These associations remained significant after excluding children with pre-existing lung disease. Higher TRAIL levels were associated with more negative values for X5 in general linear models (Mean X5 (kPa/(L/s)) in T1 (low TRAIL): −0.193 vs T3 (high TRAIL): −0.216, p-value 0.026). Conclusions: High TRAIL levels are significantly associated with markers of pulmonary airflow obstruction in school-aged children.
(Less)
- author
- Zaigham, Suneela LU ; Dencker, Magnus LU ; Karlsson, Magnus K. LU ; Thorsson, Ola LU and Wollmer, Per LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Impulse oscillometry, Lung function, Tumour necrosis factor-related apoptosis-inducing ligand
- in
- Respiratory Medicine
- volume
- 176
- article number
- 106235
- publisher
- Elsevier
- external identifiers
-
- pmid:33249302
- scopus:85096823977
- ISSN
- 0954-6111
- DOI
- 10.1016/j.rmed.2020.106235
- language
- English
- LU publication?
- yes
- id
- 627f1e60-bff9-4eb8-aa5e-cccf693d5ba5
- date added to LUP
- 2020-12-09 13:30:21
- date last changed
- 2024-09-19 11:27:06
@article{627f1e60-bff9-4eb8-aa5e-cccf693d5ba5, abstract = {{<p>Background: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with inflammatory and apoptotic properties. A complex relationship exists between TRAIL and the lung where both elevated TRAIL and TRAIL deficiency are associated with lung impairment. In neonatal mice, TRAIL is thought to translate respiratory infections into chronic lung disease but the association between TRAIL and lung function in childhood has not been assessed. Aim: To assess the cross-sectional relationship between TRAIL levels and lung function in school-aged children. Methods: The study cohort consisted of 170 school-aged children attending four schools in Malmö, Sweden. Lung volumes, impulse oscillometry (IOS) and serum TRAIL were measured for all children. Linear regression was used to assess changes in lung function per 1-SD increase in TRAIL. General linear models were used to assess mean lung function by tertiles (T) of TRAIL. Results: Mean age was 9.9 years (±0.6). A 1-SD increase in TRAIL was associated with lower values of FEV<sub>1</sub> and FEV<sub>1</sub>/VC (change in FEV<sub>1</sub> (L) and FEV<sub>1</sub>/VC ratio: −0.047, p-value 0.002, and −0.011, p-value 0.020, respectively) and higher values of lung resistance (change in R<sub>5</sub> and R<sub>20</sub> (kPa/(L/s)): 0.035, p-value <0.001 and 0.027, p-value 0.004, respectively). These associations remained significant after excluding children with pre-existing lung disease. Higher TRAIL levels were associated with more negative values for X<sub>5</sub> in general linear models (Mean X<sub>5</sub> (kPa/(L/s)) in T1 (low TRAIL): −0.193 vs T3 (high TRAIL): −0.216, p-value 0.026). Conclusions: High TRAIL levels are significantly associated with markers of pulmonary airflow obstruction in school-aged children.</p>}}, author = {{Zaigham, Suneela and Dencker, Magnus and Karlsson, Magnus K. and Thorsson, Ola and Wollmer, Per}}, issn = {{0954-6111}}, keywords = {{Impulse oscillometry; Lung function; Tumour necrosis factor-related apoptosis-inducing ligand}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Respiratory Medicine}}, title = {{Lung function is associated with tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in school-aged children}}, url = {{http://dx.doi.org/10.1016/j.rmed.2020.106235}}, doi = {{10.1016/j.rmed.2020.106235}}, volume = {{176}}, year = {{2021}}, }