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Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects.

Alsalim, Wathik LU and Ahrén, Bo LU (2019) In Endocrinology, Diabetes & Metabolism 2(2). p.1-5
Abstract
People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total... (More)
People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total (reflecting secretion) glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) with, again, no difference between the tests. Furthermore, gastric emptying, as revealed by the indirect paracetamol test, did not differ between the tests. We therefore conclude that the speed of breakfast ingestion does not affect the postprandial rise of glucose, insulin or incretin hormones in healthy subjects (Less)
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author
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publishing date
type
Contribution to journal
publication status
published
subject
in
Endocrinology, Diabetes & Metabolism
volume
2
issue
2
article number
e00056
pages
1 - 5
publisher
John Wiley & Sons Inc.
DOI
10.1002/edm2.56
language
English
LU publication?
yes
id
642c1643-5f9b-4fad-9d8f-6c016ee20f52
date added to LUP
2019-05-21 18:06:26
date last changed
2021-10-28 09:34:03
@article{642c1643-5f9b-4fad-9d8f-6c016ee20f52,
  abstract     = {{People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total (reflecting secretion) glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) with, again, no difference between the tests. Furthermore, gastric emptying, as revealed by the indirect paracetamol test, did not differ between the tests. We therefore conclude that the speed of breakfast ingestion does not affect the postprandial rise of glucose, insulin or incretin hormones in healthy subjects}},
  author       = {{Alsalim, Wathik and Ahrén, Bo}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{1--5}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Endocrinology, Diabetes & Metabolism}},
  title        = {{Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects.}},
  url          = {{http://dx.doi.org/10.1002/edm2.56}},
  doi          = {{10.1002/edm2.56}},
  volume       = {{2}},
  year         = {{2019}},
}