Advanced

Longitudinal left ventricular function is globally depressed within a week of STEMI

Pahlm, Ulrika LU ; Seemann, Felicia LU ; Engblom, Henrik LU ; Gyllenhammar, Tom LU ; Halvorsen, Sigrun; Hansen, Henrik Steen; Erlinge, David LU ; Atar, Dan; Heiberg, Einar LU and Arheden, Håkan LU , et al. (2018) In Clinical Physiology and Functional Imaging 38(6). p.1029-1037
Abstract

Sixty percent of stroke volume (SV) is generated by atrioventricular plane displacement (AVPD) in a healthy left ventricle (LV). The aims were to determine the effect of ST-elevation myocardial infarction (STEMI) on AVPD and contribution of AVPD to SV and to study the relationship between AVPD and infarct size (IS) and location. Patients from CHILL-MI and MITOCARE studies with cardiovascular magnetic resonance within a week of STEMI (n = 177, 59 ± 11 years) and healthy controls (n = 20, 62 ± 11 years) were included. Left ventricular volumes were quantified in short-axis images. AVPD was measured in six locations in long-axis images. Longitudinal contribution to SV was calculated as AVPD multiplied by the short-axis epicardial area.... (More)

Sixty percent of stroke volume (SV) is generated by atrioventricular plane displacement (AVPD) in a healthy left ventricle (LV). The aims were to determine the effect of ST-elevation myocardial infarction (STEMI) on AVPD and contribution of AVPD to SV and to study the relationship between AVPD and infarct size (IS) and location. Patients from CHILL-MI and MITOCARE studies with cardiovascular magnetic resonance within a week of STEMI (n = 177, 59 ± 11 years) and healthy controls (n = 20, 62 ± 11 years) were included. Left ventricular volumes were quantified in short-axis images. AVPD was measured in six locations in long-axis images. Longitudinal contribution to SV was calculated as AVPD multiplied by the short-axis epicardial area. Patients (IS 17 ± 10% of LV) had decreased ejection fraction (48 ± 8%) compared to controls (60 ± 5%, P<0·001). Global AVPD was decreased in patients (11 ± 2 mm versus 15 ± 2 mm in controls, P<0·001) and this held true for both infarcted and remote segments. AVPD contribution to SV was lower in patients (58 ± 9%) than in controls (64 ± 8%) (P<0·001). There was a weak negative correlation between IS and AVPD (r2=0·06) but no differences in global AVPD linked to infarct location. Decrease in global and regional AVPD occur even in remote myocardium within 1 week of STEMI. Global AVPD decrease is independent of MI location, and MI size has only minor effect. Longitudinal pumping is slightly lower compared to controls but remains to be the main component to SV even after STEMI. These results highlight the difficulty in determining infarct location and size from longitudinal measures of LV function.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiac magnetic resonance, heart failure, left ventricular function, myocardial infarction, regional function
in
Clinical Physiology and Functional Imaging
volume
38
issue
6
pages
9 pages
publisher
Wiley Online Library
external identifiers
  • scopus:85054198207
ISSN
1475-0961
DOI
10.1111/cpf.12521
language
English
LU publication?
yes
id
64393ab6-5088-4787-bb00-f1a5fcf9d323
date added to LUP
2018-10-09 08:35:25
date last changed
2019-09-17 04:40:14
@article{64393ab6-5088-4787-bb00-f1a5fcf9d323,
  abstract     = {<p>Sixty percent of stroke volume (SV) is generated by atrioventricular plane displacement (AVPD) in a healthy left ventricle (LV). The aims were to determine the effect of ST-elevation myocardial infarction (STEMI) on AVPD and contribution of AVPD to SV and to study the relationship between AVPD and infarct size (IS) and location. Patients from CHILL-MI and MITOCARE studies with cardiovascular magnetic resonance within a week of STEMI (n = 177, 59 ± 11 years) and healthy controls (n = 20, 62 ± 11 years) were included. Left ventricular volumes were quantified in short-axis images. AVPD was measured in six locations in long-axis images. Longitudinal contribution to SV was calculated as AVPD multiplied by the short-axis epicardial area. Patients (IS 17 ± 10% of LV) had decreased ejection fraction (48 ± 8%) compared to controls (60 ± 5%, P&lt;0·001). Global AVPD was decreased in patients (11 ± 2 mm versus 15 ± 2 mm in controls, P&lt;0·001) and this held true for both infarcted and remote segments. AVPD contribution to SV was lower in patients (58 ± 9%) than in controls (64 ± 8%) (P&lt;0·001). There was a weak negative correlation between IS and AVPD (r<sup>2</sup>=0·06) but no differences in global AVPD linked to infarct location. Decrease in global and regional AVPD occur even in remote myocardium within 1 week of STEMI. Global AVPD decrease is independent of MI location, and MI size has only minor effect. Longitudinal pumping is slightly lower compared to controls but remains to be the main component to SV even after STEMI. These results highlight the difficulty in determining infarct location and size from longitudinal measures of LV function.</p>},
  author       = {Pahlm, Ulrika and Seemann, Felicia and Engblom, Henrik and Gyllenhammar, Tom and Halvorsen, Sigrun and Hansen, Henrik Steen and Erlinge, David and Atar, Dan and Heiberg, Einar and Arheden, Håkan and Carlsson, Marcus},
  issn         = {1475-0961},
  keyword      = {cardiac magnetic resonance,heart failure,left ventricular function,myocardial infarction,regional function},
  language     = {eng},
  number       = {6},
  pages        = {1029--1037},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Longitudinal left ventricular function is globally depressed within a week of STEMI},
  url          = {http://dx.doi.org/10.1111/cpf.12521},
  volume       = {38},
  year         = {2018},
}