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Cerebral perfusion in the elderly with nocturnal blood pressure fall

Siennicki-Lantz, Arkadiusz LU ; Reinprecht, Faina LU ; Axelsson, Johan LU and Elmståhl, Sölve LU (2007) In European Journal of Neurology 14(7). p.715-720
Abstract
Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing... (More)
Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing systolic BP during the 14-year period was observed in the subgroup with extreme nocturnal diastolic BP dip, irrespectively of BP values or prevalence of hypertension. Extreme nocturnal diastolic BP fall in a cohort of elderly men is correlated with focal changes in CBF. Further studies could explain if increasing BP in the elderly is a cause or result of pathological autoregulation, and if antihypertensive treatment increases nocturnal BP dip. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral blood, ambulatory blood pressure monitoring, blood pressure, flow, cohort, elderly
in
European Journal of Neurology
volume
14
issue
7
pages
715 - 720
publisher
Wiley-Blackwell
external identifiers
  • wos:000247561200013
  • scopus:34347332436
ISSN
1351-5101
DOI
10.1111/j.1468-1331.2007.01805.x
language
English
LU publication?
yes
id
94f5a710-42cf-4e90-9072-60ebf9a7d0d9 (old id 647770)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17594325&dopt=Abstract
date added to LUP
2007-12-14 15:38:34
date last changed
2017-03-26 03:27:06
@article{94f5a710-42cf-4e90-9072-60ebf9a7d0d9,
  abstract     = {Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing systolic BP during the 14-year period was observed in the subgroup with extreme nocturnal diastolic BP dip, irrespectively of BP values or prevalence of hypertension. Extreme nocturnal diastolic BP fall in a cohort of elderly men is correlated with focal changes in CBF. Further studies could explain if increasing BP in the elderly is a cause or result of pathological autoregulation, and if antihypertensive treatment increases nocturnal BP dip.},
  author       = {Siennicki-Lantz, Arkadiusz and Reinprecht, Faina and Axelsson, Johan and Elmståhl, Sölve},
  issn         = {1351-5101},
  keyword      = {cerebral blood,ambulatory blood pressure monitoring,blood pressure,flow,cohort,elderly},
  language     = {eng},
  number       = {7},
  pages        = {715--720},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neurology},
  title        = {Cerebral perfusion in the elderly with nocturnal blood pressure fall},
  url          = {http://dx.doi.org/10.1111/j.1468-1331.2007.01805.x},
  volume       = {14},
  year         = {2007},
}