Cerebral perfusion in the elderly with nocturnal blood pressure fall
Siennicki-Lantz, Arkadiusz LU
; Reinprecht, Faina
LU
; Axelsson, Johan
LU
and Elmståhl, Sölve
LU
(2007)
In European Journal of Neurology
14(7).
p.715-720
- Abstract
- Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing... (More)
- Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing systolic BP during the 14-year period was observed in the subgroup with extreme nocturnal diastolic BP dip, irrespectively of BP values or prevalence of hypertension. Extreme nocturnal diastolic BP fall in a cohort of elderly men is correlated with focal changes in CBF. Further studies could explain if increasing BP in the elderly is a cause or result of pathological autoregulation, and if antihypertensive treatment increases nocturnal BP dip. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/647770
- author
- Siennicki-Lantz, Arkadiusz
LU
; Reinprecht, Faina
LU
; Axelsson, Johan
LU
and Elmståhl, Sölve
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cerebral blood, ambulatory blood pressure monitoring, blood pressure, flow, cohort, elderly
- in
- European Journal of Neurology
- volume
- 14
- issue
- 7
- pages
- 715 - 720
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000247561200013
- scopus:34347332436
- ISSN
- 1351-5101
- DOI
- 10.1111/j.1468-1331.2007.01805.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Malmö (013027010), Division of Geriatric Medicine (013040040), Department of Health Sciences (013220000)
- id
- 94f5a710-42cf-4e90-9072-60ebf9a7d0d9 (old id 647770)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17594325&dopt=Abstract
- date added to LUP
- 2016-04-01 11:40:50
- date last changed
- 2023-01-02 21:47:51
@article{94f5a710-42cf-4e90-9072-60ebf9a7d0d9,
abstract = {{Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing systolic BP during the 14-year period was observed in the subgroup with extreme nocturnal diastolic BP dip, irrespectively of BP values or prevalence of hypertension. Extreme nocturnal diastolic BP fall in a cohort of elderly men is correlated with focal changes in CBF. Further studies could explain if increasing BP in the elderly is a cause or result of pathological autoregulation, and if antihypertensive treatment increases nocturnal BP dip.}},
author = {{Siennicki-Lantz, Arkadiusz and Reinprecht, Faina and Axelsson, Johan and Elmståhl, Sölve}},
issn = {{1351-5101}},
keywords = {{cerebral blood; ambulatory blood pressure monitoring; blood pressure; flow; cohort; elderly}},
language = {{eng}},
number = {{7}},
pages = {{715--720}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neurology}},
title = {{Cerebral perfusion in the elderly with nocturnal blood pressure fall}},
url = {{http://dx.doi.org/10.1111/j.1468-1331.2007.01805.x}},
doi = {{10.1111/j.1468-1331.2007.01805.x}},
volume = {{14}},
year = {{2007}},
}