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Radiotherapy and tamoxifen after mastectomy in postmenopausal women - 20 year follow-up of the South Sweden Breast Cancer group randomised trial SSBCG II : I

Killander, Fredrika LU ; Anderson, Harald LU ; Ryden, Stefan; Möller, Torgil LU ; Aspegrend, Knut; Ceberg, Jeanette; Danewid, Christina and Malmström, Per LU (2007) In European Journal of Cancer 43(14). p.2100-2108
Abstract
Aims: To evaluate long-term effects of radiotherapy and tamoxifen after mastectomy on recurrence and survival in stage II breast cancer. Methods: A randomised phase III study with three treatment alternatives. (1) Radiotherapy 50 Gy/2S fractions to chest wall and regional lymph nodes (RT). (2) Radiotherapy and tamoxifen 30 mg/day for one year (RT + tam) and 3. Tamoxifen (tam). Results: 724 postmenopausal women were included between 1978 and 1985 and the trial was close to population based. Follow-up for survival was 23 years. Locoregional recurrences were reduced from 18.5% in the tam arm to 5.3% in the RT + tam arm. Overall mortality at 20 years was 71% in the RT arm, 68% in the RT + tam arm and 62% in the tam arm. The difference between... (More)
Aims: To evaluate long-term effects of radiotherapy and tamoxifen after mastectomy on recurrence and survival in stage II breast cancer. Methods: A randomised phase III study with three treatment alternatives. (1) Radiotherapy 50 Gy/2S fractions to chest wall and regional lymph nodes (RT). (2) Radiotherapy and tamoxifen 30 mg/day for one year (RT + tam) and 3. Tamoxifen (tam). Results: 724 postmenopausal women were included between 1978 and 1985 and the trial was close to population based. Follow-up for survival was 23 years. Locoregional recurrences were reduced from 18.5% in the tam arm to 5.3% in the RT + tam arm. Overall mortality at 20 years was 71% in the RT arm, 68% in the RT + tam arm and 62% in the tam arm. The difference between RT + tam and tam was not significant except in the receptor positive subgroup in favour of non-irradiated patients (p = 0.047). The cumulative incidence of systemic disease at 20 years was lower in the RT + Tam arm than in the RT arm, 40% versus 50% (p = 0.047). Conclusion: Postmastectomy radiotherapy significantly reduced loco-regional recurrences, but overall survival was not improved. At 20 years, a lower mortality was recorded for non-irradiated patients treated with tam. (C) 2007 Published by Elsevier Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
local recurrence, radiotherapy, breast cancer, mastectomy, mortality, long-term, tamoxifen
in
European Journal of Cancer
volume
43
issue
14
pages
2100 - 2108
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000250186100019
  • scopus:34548479956
ISSN
1879-0852
DOI
10.1016/j.ejca.2007.05.026
language
English
LU publication?
yes
id
68ef6c1b-942b-434e-aec1-c1f84a6fe376 (old id 655358)
date added to LUP
2007-12-13 16:43:26
date last changed
2017-01-01 05:07:55
@article{68ef6c1b-942b-434e-aec1-c1f84a6fe376,
  abstract     = {Aims: To evaluate long-term effects of radiotherapy and tamoxifen after mastectomy on recurrence and survival in stage II breast cancer. Methods: A randomised phase III study with three treatment alternatives. (1) Radiotherapy 50 Gy/2S fractions to chest wall and regional lymph nodes (RT). (2) Radiotherapy and tamoxifen 30 mg/day for one year (RT + tam) and 3. Tamoxifen (tam). Results: 724 postmenopausal women were included between 1978 and 1985 and the trial was close to population based. Follow-up for survival was 23 years. Locoregional recurrences were reduced from 18.5% in the tam arm to 5.3% in the RT + tam arm. Overall mortality at 20 years was 71% in the RT arm, 68% in the RT + tam arm and 62% in the tam arm. The difference between RT + tam and tam was not significant except in the receptor positive subgroup in favour of non-irradiated patients (p = 0.047). The cumulative incidence of systemic disease at 20 years was lower in the RT + Tam arm than in the RT arm, 40% versus 50% (p = 0.047). Conclusion: Postmastectomy radiotherapy significantly reduced loco-regional recurrences, but overall survival was not improved. At 20 years, a lower mortality was recorded for non-irradiated patients treated with tam. (C) 2007 Published by Elsevier Ltd.},
  author       = {Killander, Fredrika and Anderson, Harald and Ryden, Stefan and Möller, Torgil and Aspegrend, Knut and Ceberg, Jeanette and Danewid, Christina and Malmström, Per},
  issn         = {1879-0852},
  keyword      = {local recurrence,radiotherapy,breast cancer,mastectomy,mortality,long-term,tamoxifen},
  language     = {eng},
  number       = {14},
  pages        = {2100--2108},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Radiotherapy and tamoxifen after mastectomy in postmenopausal women - 20 year follow-up of the South Sweden Breast Cancer group randomised trial SSBCG II : I},
  url          = {http://dx.doi.org/10.1016/j.ejca.2007.05.026},
  volume       = {43},
  year         = {2007},
}