A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus
(2007) In Tissue Antigens 70(5). p.412-414- Abstract
- Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular... (More)
- Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/655574
- author
- Linga-Reddy, M. V. Prasad ; Gunnarsson, I. ; Svenungsson, E. ; Sturfelt, Gunnar LU ; Jönsen, Andreas LU ; Truedsson, Lennart LU ; Nordmark, G ; Ronnblom, L. and Alarcon-Riquelme, M. E.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- transactivator, class II transactivator, major histocompatibility complex class II, systemic lupus erythematosus
- in
- Tissue Antigens
- volume
- 70
- issue
- 5
- pages
- 412 - 414
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000249994900008
- scopus:35148867770
- ISSN
- 0001-2815
- DOI
- 10.1111/j.1399-0039.2007.00920.x
- language
- English
- LU publication?
- yes
- id
- 4846328b-aa45-4627-ba84-5169bdb32187 (old id 655574)
- date added to LUP
- 2016-04-01 17:12:05
- date last changed
- 2022-01-29 01:06:17
@article{4846328b-aa45-4627-ba84-5169bdb32187, abstract = {{Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE.}}, author = {{Linga-Reddy, M. V. Prasad and Gunnarsson, I. and Svenungsson, E. and Sturfelt, Gunnar and Jönsen, Andreas and Truedsson, Lennart and Nordmark, G and Ronnblom, L. and Alarcon-Riquelme, M. E.}}, issn = {{0001-2815}}, keywords = {{transactivator; class II transactivator; major histocompatibility complex class II; systemic lupus erythematosus}}, language = {{eng}}, number = {{5}}, pages = {{412--414}}, publisher = {{Wiley-Blackwell}}, series = {{Tissue Antigens}}, title = {{A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus}}, url = {{http://dx.doi.org/10.1111/j.1399-0039.2007.00920.x}}, doi = {{10.1111/j.1399-0039.2007.00920.x}}, volume = {{70}}, year = {{2007}}, }