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A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus

Linga-Reddy, M. V. Prasad; Gunnarsson, I.; Svenungsson, E.; Sturfelt, Gunnar LU ; Jönsen, Andreas LU ; Truedsson, Lennart LU ; Nordmark, G; Ronnblom, L. and Alarcon-Riquelme, M. E. (2007) In Tissue Antigens 70(5). p.412-414
Abstract
Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular... (More)
Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transactivator, class II transactivator, major histocompatibility complex class II, systemic lupus erythematosus
in
Tissue Antigens
volume
70
issue
5
pages
412 - 414
publisher
Wiley-Blackwell
external identifiers
  • wos:000249994900008
  • scopus:35148867770
ISSN
0001-2815
DOI
10.1111/j.1399-0039.2007.00920.x
language
English
LU publication?
yes
id
4846328b-aa45-4627-ba84-5169bdb32187 (old id 655574)
date added to LUP
2007-12-17 08:51:37
date last changed
2017-11-15 14:17:22
@article{4846328b-aa45-4627-ba84-5169bdb32187,
  abstract     = {Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE.},
  author       = {Linga-Reddy, M. V. Prasad and Gunnarsson, I. and Svenungsson, E. and Sturfelt, Gunnar and Jönsen, Andreas and Truedsson, Lennart and Nordmark, G and Ronnblom, L. and Alarcon-Riquelme, M. E.},
  issn         = {0001-2815},
  keyword      = {transactivator,class II transactivator,major histocompatibility complex class II,systemic lupus erythematosus},
  language     = {eng},
  number       = {5},
  pages        = {412--414},
  publisher    = {Wiley-Blackwell},
  series       = {Tissue Antigens},
  title        = {A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1111/j.1399-0039.2007.00920.x},
  volume       = {70},
  year         = {2007},
}