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Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Ferrari, Pietro; Jenab, Mazda; Norat, Teresa; Moskal, Aurelie; Slimani, Nadia; Olsen, Anja; Tjonneland, Anne; Overvad, Kim; Jensen, Majken K. and Boutron-Ruault, Marie-Christine, et al. (2007) In International Journal of Cancer 121(9). p.2065-2072
Abstract
Alcohol consumption may be associated with risk of colorectal cancer (CRC), but the epidemiological evidence for an association with specific anatomical subsites, types of alcoholic beverages and current vs. lifetime alcohol intake is inconsistent. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 478,732 study subjects free of cancer at enrolment between 1992 and 2000 were followed up for an average of 6.2 years, during which 1,833 CRC cases were observed. Detailed information on consumption of alcoholic beverages at baseline (all cases) and during lifetime (1,447 CRC cases, 69% of the cohort) was collected from questionnaires. Cox proportional hazard models were used to examine the alcohol-CRC association.... (More)
Alcohol consumption may be associated with risk of colorectal cancer (CRC), but the epidemiological evidence for an association with specific anatomical subsites, types of alcoholic beverages and current vs. lifetime alcohol intake is inconsistent. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 478,732 study subjects free of cancer at enrolment between 1992 and 2000 were followed up for an average of 6.2 years, during which 1,833 CRC cases were observed. Detailed information on consumption of alcoholic beverages at baseline (all cases) and during lifetime (1,447 CRC cases, 69% of the cohort) was collected from questionnaires. Cox proportional hazard models were used to examine the alcohol-CRC association. After adjustment for potential confounding factors, lifetime alcohol intake was significantly positively associated to CRC risk (hazard ratio, HR = 1.08, 95% CI = 1.04-1.12 for 15 g/day increase), with higher cancer risks observed in the rectum (HR = 1.12, 95% CI = 1.06-1.18) than distal colon (HR = 1.08, 95% CI = 1.01-1.16), and proximal colon (HR = 1.02, 95% CI = 0.92-1.12). Similar results were observed for baseline alcohol intake. When assessed by alcoholic beverages at baseline, the CRC risk for beer (HR = 1.38, 95% CI `= 1.08-1.77 for 20-39.9 vs. 0.1-2.9 g/day) was higher than wine (HR = 1.21, 95% CI = 1.02-1.44), although the two risk estimates were not significantly different from each other. Higher HRs for baseline alcohol were observed for low levels of folate intake (1.13, 95% CI = 1.06-1.20 for 15 g/day increase) compared to high folate intake (1.03, 95% CI = 0.98-1.09). In this large European cohort, both lifetime and baseline alcohol consumption increase colon and rectum cancer risk, with more apparent risk increases for alcohol intakes greater than 30 g/day. (c) 2007 Wiley-Liss, Inc. (Less)
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publication status
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subject
keywords
prospective study, colorectal cancer, alcohol, lifetime exposure
in
International Journal of Cancer
volume
121
issue
9
pages
2065 - 2072
publisher
John Wiley & Sons
external identifiers
  • wos:000249718100024
  • scopus:34648816369
ISSN
0020-7136
DOI
10.1002/ijc.22966
language
English
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yes
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4646c101-b522-4e19-8c3b-4c0907029f47 (old id 656084)
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2007-12-11 14:19:38
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2017-10-22 03:49:52
@article{4646c101-b522-4e19-8c3b-4c0907029f47,
  abstract     = {Alcohol consumption may be associated with risk of colorectal cancer (CRC), but the epidemiological evidence for an association with specific anatomical subsites, types of alcoholic beverages and current vs. lifetime alcohol intake is inconsistent. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 478,732 study subjects free of cancer at enrolment between 1992 and 2000 were followed up for an average of 6.2 years, during which 1,833 CRC cases were observed. Detailed information on consumption of alcoholic beverages at baseline (all cases) and during lifetime (1,447 CRC cases, 69% of the cohort) was collected from questionnaires. Cox proportional hazard models were used to examine the alcohol-CRC association. After adjustment for potential confounding factors, lifetime alcohol intake was significantly positively associated to CRC risk (hazard ratio, HR = 1.08, 95% CI = 1.04-1.12 for 15 g/day increase), with higher cancer risks observed in the rectum (HR = 1.12, 95% CI = 1.06-1.18) than distal colon (HR = 1.08, 95% CI = 1.01-1.16), and proximal colon (HR = 1.02, 95% CI = 0.92-1.12). Similar results were observed for baseline alcohol intake. When assessed by alcoholic beverages at baseline, the CRC risk for beer (HR = 1.38, 95% CI `= 1.08-1.77 for 20-39.9 vs. 0.1-2.9 g/day) was higher than wine (HR = 1.21, 95% CI = 1.02-1.44), although the two risk estimates were not significantly different from each other. Higher HRs for baseline alcohol were observed for low levels of folate intake (1.13, 95% CI = 1.06-1.20 for 15 g/day increase) compared to high folate intake (1.03, 95% CI = 0.98-1.09). In this large European cohort, both lifetime and baseline alcohol consumption increase colon and rectum cancer risk, with more apparent risk increases for alcohol intakes greater than 30 g/day. (c) 2007 Wiley-Liss, Inc.},
  author       = {Ferrari, Pietro and Jenab, Mazda and Norat, Teresa and Moskal, Aurelie and Slimani, Nadia and Olsen, Anja and Tjonneland, Anne and Overvad, Kim and Jensen, Majken K. and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Morois, Sophie and Rohrmann, Sabine and Linseisen, Jakob and Boeing, Heiner and Bergmann, Manuela and Kontopoulou, Dimitra and Trichopoulou, Antonia and Kassapa, Christina and Masala, Giovanna and Krogh, Vittorio and Vineis, Paolo and Panico, Salvatore and Tumino, Rosario and van Gils, Carla H. and Peeters, Petra and Bueno-de-Mesquita, H. Bas and Ocke, Marga C. and Skeie, Guri and Lund, Eiliv and Agudo, Antonio and Ardanaz, Eva and Lopez, Dolores C. and Sanchez, Maria-Jose and Quiros, Jose R. and Amiano, Pilar and Berglund, Göran and Manjer, Jonas and Palmqvist, Richard and Van Guelpen, Bethany and Allen, Naomi and Key, Tim and Bingham, Sheila and Mazuir, Mathieu and Boffetta, Paolo and Kaaks, Rudolf and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {prospective study,colorectal cancer,alcohol,lifetime exposure},
  language     = {eng},
  number       = {9},
  pages        = {2065--2072},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1002/ijc.22966},
  volume       = {121},
  year         = {2007},
}