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Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus

Sanchez, Elena; Abelson, Anna-Karin; Sabio, Jose M.; Gonzalez-Gay, Miguel A.; Ortego-Centeno, Norberto; Jimenez-Alonso, Juan; de Ramon, Enrique; Sanchez-Roman, Julio; Lopez-Nevot, Miguel A. and Gunnarsson, Iva, et al. (2007) In Arthritis and Rheumatism 56(9). p.3080-3086
Abstract
Objective. To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods. We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphism was genotyped by polymerase chain reaction, using a predeveloped TaqMan allele discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results. In the Spanish cohort there was a statistically significant difference in the distribution of the CD24 V allele between SLE patients and controls (OR 3.6 [95% CI... (More)
Objective. To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods. We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphism was genotyped by polymerase chain reaction, using a predeveloped TaqMan allele discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results. In the Spanish cohort there was a statistically significant difference in the distribution of the CD24 V allele between SLE patients and controls (OR 3.6 [95% CI 2.13-6.16], P < 0.0001). In addition, frequency of the CD24 V/V genotype was increased in SLE patients compared with controls (OR 3.7 [95% CI 2.16-6.34], P < 0.00001). We sought to replicate this association with SLE in a German population and a Swedish population. A similar trend was found in the German group. The CD24 V/V genotype and the CD24 V allele were more frequent in SLE patients than in controls, although this difference was not statistically significant. No differences were observed in the Swedish group. A meta-analysis of the Spanish and German cohorts demonstrated that the CD24 V allele has a risk effect in SLE patients (pooled OR 1.25 [95% Cl 1.08-1.46], P = 0.003). In addition, homozygosity for the CD24 V risk allele significantly increased the effect (pooled OR 2.1,9 [95% Cl 1.50-3.22], P = 0.00007). Conclusion. These findings suggest that the CD24 A57V polymorphism plays a role in susceptibility to SLE in a Spanish population. (Less)
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type
Contribution to journal
publication status
published
subject
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Arthritis and Rheumatism
volume
56
issue
9
pages
3080 - 3086
publisher
John Wiley & Sons
external identifiers
  • wos:000249832600030
  • scopus:34848914129
ISSN
1529-0131
DOI
10.1002/art.22871
language
English
LU publication?
yes
id
ee0d2971-148b-4c05-99ba-633e9d3ee378 (old id 656270)
date added to LUP
2007-12-21 14:51:05
date last changed
2017-07-23 03:45:42
@article{ee0d2971-148b-4c05-99ba-633e9d3ee378,
  abstract     = {Objective. To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods. We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphism was genotyped by polymerase chain reaction, using a predeveloped TaqMan allele discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results. In the Spanish cohort there was a statistically significant difference in the distribution of the CD24 V allele between SLE patients and controls (OR 3.6 [95% CI 2.13-6.16], P &lt; 0.0001). In addition, frequency of the CD24 V/V genotype was increased in SLE patients compared with controls (OR 3.7 [95% CI 2.16-6.34], P &lt; 0.00001). We sought to replicate this association with SLE in a German population and a Swedish population. A similar trend was found in the German group. The CD24 V/V genotype and the CD24 V allele were more frequent in SLE patients than in controls, although this difference was not statistically significant. No differences were observed in the Swedish group. A meta-analysis of the Spanish and German cohorts demonstrated that the CD24 V allele has a risk effect in SLE patients (pooled OR 1.25 [95% Cl 1.08-1.46], P = 0.003). In addition, homozygosity for the CD24 V risk allele significantly increased the effect (pooled OR 2.1,9 [95% Cl 1.50-3.22], P = 0.00007). Conclusion. These findings suggest that the CD24 A57V polymorphism plays a role in susceptibility to SLE in a Spanish population.},
  author       = {Sanchez, Elena and Abelson, Anna-Karin and Sabio, Jose M. and Gonzalez-Gay, Miguel A. and Ortego-Centeno, Norberto and Jimenez-Alonso, Juan and de Ramon, Enrique and Sanchez-Roman, Julio and Lopez-Nevot, Miguel A. and Gunnarsson, Iva and Svenungsson, Elisabet and Sturfelt, Gunnar and Truedsson, Lennart and Jönsen, Andreas and Francisca Gonzalez-Escribano, Maria and Witte, Torsten and Alarcon-Riquelme, Marta E. and Martin, Javier},
  issn         = {1529-0131},
  language     = {eng},
  number       = {9},
  pages        = {3080--3086},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis and Rheumatism},
  title        = {Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1002/art.22871},
  volume       = {56},
  year         = {2007},
}