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Coronary flow velocity reserve reduction is comparable in patients with erectile dysfunction and in patients with impaired fasting glucose or well-regulated diabetes mellitus

Borgquist, Rasmus LU ; Nilsson, Peter LU ; Gudmundsson, Petri; Winter, Reidar LU ; Leosdottir, Margrét LU and Willenheimer, Ronnie LU (2007) In European Journal of Cardiovascular Prevention & Rehabilitation 14(2). p.258-264
Abstract
Background There is growing evidence that erectile dysfunction is a sentinel for future coronary artery disease. Recently published studies have shown signs of impaired coronary endothelial function in patients with erectile dysfunction, without clinical cardiovascular disease and diabetes. We evaluated the magnitude of coronary vasodilatory dysfunction in men with erectile dysfunction, as compared with men with impaired glucose metabolism (impaired fasting glucose or diabetes) and healthy controls. Methods We investigated men aged 68-73 years with erectile dysfunction (n=12), age-matched men with impaired glucose metabolism, who all proved to have erectile dysfunction (n=15), and age-matched male controls (n=12). Erectile dysfunction was... (More)
Background There is growing evidence that erectile dysfunction is a sentinel for future coronary artery disease. Recently published studies have shown signs of impaired coronary endothelial function in patients with erectile dysfunction, without clinical cardiovascular disease and diabetes. We evaluated the magnitude of coronary vasodilatory dysfunction in men with erectile dysfunction, as compared with men with impaired glucose metabolism (impaired fasting glucose or diabetes) and healthy controls. Methods We investigated men aged 68-73 years with erectile dysfunction (n=12), age-matched men with impaired glucose metabolism, who all proved to have erectile dysfunction (n=15), and age-matched male controls (n=12). Erectile dysfunction was evaluated using the International Index of Erectile Function (IIEF)-5 questionnaire. Coronary flow velocity reserve in the left anterior descending artery was examined using Doppler ultrasound and intravenous adenosine provocation. Results Coronary flow velocities at rest did not differ between the three groups, but maximum coronary flow velocity was significantly lower in the erectile dysfunction group (P= 0.004) and in the impaired glucose metabolism group (P= 0.019), as compared with controls. There was no difference between the erectile dysfunction and impaired glucose metabolism groups. Coronary flow velocity reserve was reduced in the erectile dysfunction group (P=0.026) compared to controls, but was similar compared to the impaired glucose metabolism group. In multivariate analysis including all groups, erectile dysfunction score was the only independent predictor of reduced coronary flow velocity reserve (P=0.020). Conclusions The magnitude of early coronary endothelial and smooth muscle cell dysfunction in otherwise healthy men with erectile dysfunction was comparable to that of patients with impaired glucose metabolism: a well known risk factor for coronary artery disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dysfunction, endothelial, risk factors, erectile dysfunction, ischemic heart disease, coronary microcirculation
in
European Journal of Cardiovascular Prevention & Rehabilitation
volume
14
issue
2
pages
258 - 264
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000245958000014
  • scopus:34247497405
ISSN
1741-8275
DOI
10.1097/HJR.0b013e328021072b
language
English
LU publication?
yes
id
79282a02-aede-4ff0-bac5-2a2058feb5a0 (old id 663615)
alternative location
http://www.jcardiovascularrisk.com/pt/re/ejcpr/abstract.00149831-200704000-00014.htm
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17446805&dopt=Abstract
date added to LUP
2007-12-11 15:25:58
date last changed
2017-01-01 04:38:49
@article{79282a02-aede-4ff0-bac5-2a2058feb5a0,
  abstract     = {Background There is growing evidence that erectile dysfunction is a sentinel for future coronary artery disease. Recently published studies have shown signs of impaired coronary endothelial function in patients with erectile dysfunction, without clinical cardiovascular disease and diabetes. We evaluated the magnitude of coronary vasodilatory dysfunction in men with erectile dysfunction, as compared with men with impaired glucose metabolism (impaired fasting glucose or diabetes) and healthy controls. Methods We investigated men aged 68-73 years with erectile dysfunction (n=12), age-matched men with impaired glucose metabolism, who all proved to have erectile dysfunction (n=15), and age-matched male controls (n=12). Erectile dysfunction was evaluated using the International Index of Erectile Function (IIEF)-5 questionnaire. Coronary flow velocity reserve in the left anterior descending artery was examined using Doppler ultrasound and intravenous adenosine provocation. Results Coronary flow velocities at rest did not differ between the three groups, but maximum coronary flow velocity was significantly lower in the erectile dysfunction group (P= 0.004) and in the impaired glucose metabolism group (P= 0.019), as compared with controls. There was no difference between the erectile dysfunction and impaired glucose metabolism groups. Coronary flow velocity reserve was reduced in the erectile dysfunction group (P=0.026) compared to controls, but was similar compared to the impaired glucose metabolism group. In multivariate analysis including all groups, erectile dysfunction score was the only independent predictor of reduced coronary flow velocity reserve (P=0.020). Conclusions The magnitude of early coronary endothelial and smooth muscle cell dysfunction in otherwise healthy men with erectile dysfunction was comparable to that of patients with impaired glucose metabolism: a well known risk factor for coronary artery disease.},
  author       = {Borgquist, Rasmus and Nilsson, Peter and Gudmundsson, Petri and Winter, Reidar and Leosdottir, Margrét and Willenheimer, Ronnie},
  issn         = {1741-8275},
  keyword      = {dysfunction,endothelial,risk factors,erectile dysfunction,ischemic heart disease,coronary microcirculation},
  language     = {eng},
  number       = {2},
  pages        = {258--264},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cardiovascular Prevention & Rehabilitation},
  title        = {Coronary flow velocity reserve reduction is comparable in patients with erectile dysfunction and in patients with impaired fasting glucose or well-regulated diabetes mellitus},
  url          = {http://dx.doi.org/10.1097/HJR.0b013e328021072b},
  volume       = {14},
  year         = {2007},
}