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EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries

Danesh, John; Saracci, Rodolfo; Berglund, Göran LU ; Feskens, Edith; Overvad, Kim; Panico, Salvatore; Thompson, Simon; Fournier, Agnes; Clavel-Chapelon, Francoise and Canonico, Marianne, et al. (2007) In European Journal of Epidemiology 22(2). p.129-141
Abstract
EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition ( EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle ( especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants ( 366,521 women and 153,457 men, mostly aged 35 - 70 years) in 23 centres in 10 European countries commenced follow-up for causespecific mortality,... (More)
EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition ( EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle ( especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants ( 366,521 women and 153,457 men, mostly aged 35 - 70 years) in 23 centres in 10 European countries commenced follow-up for causespecific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors. (Less)
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publication status
published
subject
keywords
prospective study, diet, EPIC heart, study protocol
in
European Journal of Epidemiology
volume
22
issue
2
pages
129 - 141
publisher
Springer
external identifiers
  • wos:000245132100008
  • scopus:33947383651
ISSN
1573-7284
DOI
10.1007/s10654-006-9096-8
language
English
LU publication?
yes
id
8fd08080-afa3-44a6-aa68-bc657bc3b486 (old id 669767)
date added to LUP
2007-12-11 17:08:00
date last changed
2017-09-17 05:25:05
@article{8fd08080-afa3-44a6-aa68-bc657bc3b486,
  abstract     = {EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition ( EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle ( especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants ( 366,521 women and 153,457 men, mostly aged 35 - 70 years) in 23 centres in 10 European countries commenced follow-up for causespecific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.},
  author       = {Danesh, John and Saracci, Rodolfo and Berglund, Göran and Feskens, Edith and Overvad, Kim and Panico, Salvatore and Thompson, Simon and Fournier, Agnes and Clavel-Chapelon, Francoise and Canonico, Marianne and Kaaks, Rudolf and Linseisen, Jakob and Boeing, Heiner and Pischon, Tobias and Weikert, Cornelia and Olsen, Anja and Tjonneland, Anne and Johnsen, Soren Paaske and Jensen, Majken Karoline and Quiros, Jose R. and Gonzalez Svatetz, Carlos Alberto and Sanchez Perez, Maria-Jose and Larranaga, Nerea and Navarro Sanchez, Carmen and Moreno Iribas, Concepcion and Bingham, Sheila and Khaw, Kay-Tee and Wareham, Nick and Key, Timothy and Roddam, Andrew and Trichopoulou, Antonia and Benetou, Vassiliki and Trichopoulos, Dimitrios and Masala, Giovanna and Sieri, Sabina and Tumino, Rosario and Sacerdote, Carlotta and Mattiello, Amalia and Verschuren, W. M. Monique and Bueno-de-Mesquita, H. Bas and Grobbee, Diederick E. and van der Schouw, Yvonne T. and Melander, Olle and Hallmans, Goran and Wennberg, Patrik and Lund, Eiliv and Kumle, Merethe and Skeie, Guri and Ferrari, Pietro and Slimani, Nadia and Norat, Teresa and Riboli, Elio},
  issn         = {1573-7284},
  keyword      = {prospective study,diet,EPIC heart,study protocol},
  language     = {eng},
  number       = {2},
  pages        = {129--141},
  publisher    = {Springer},
  series       = {European Journal of Epidemiology},
  title        = {EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries},
  url          = {http://dx.doi.org/10.1007/s10654-006-9096-8},
  volume       = {22},
  year         = {2007},
}