Appetite suppression through delayed fat digestion
(2006) In Physiology & Behavior 89(4). p.563-568- Abstract
- High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancreatic lipase/colipase secretion, compensating the impaired lipolysis by the added compound. The animals also had an elevated CCK secretion. The satiety for fat may be the consequence of elevated CCK and procolipase/enterostatin levels. We conclude that compounds can be found that delay intestinal fat... (More)
- High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancreatic lipase/colipase secretion, compensating the impaired lipolysis by the added compound. The animals also had an elevated CCK secretion. The satiety for fat may be the consequence of elevated CCK and procolipase/enterostatin levels. We conclude that compounds can be found that delay intestinal fat digestion and control high-fat food intake through the release of satiety signals, without causing steatorrhea. The absence of steatorrhea makes such compounds advantageous over lipase inhibitors in the treatment of obesity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/683561
- author
- Mei, Jie LU ; Lindqvist, Andreas LU ; Krabisch, Lennart LU ; Rehfeld, Jens F. and Erlanson-Albertsson, Charlotte LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- enterostatin, high-fat food intake, satiety, blood lipids, fecal fat, lipase, CCK, inhibitor
- in
- Physiology & Behavior
- volume
- 89
- issue
- 4
- pages
- 563 - 568
- publisher
- Elsevier
- external identifiers
-
- wos:000242539600016
- scopus:33750968773
- pmid:16952381
- ISSN
- 1873-507X
- DOI
- 10.1016/j.physbeh.2006.07.020
- language
- English
- LU publication?
- yes
- id
- 3932f424-1d6b-44dd-bc04-abe2c92c34ef (old id 683561)
- date added to LUP
- 2016-04-01 16:20:09
- date last changed
- 2022-01-28 19:01:16
@article{3932f424-1d6b-44dd-bc04-abe2c92c34ef, abstract = {{High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancreatic lipase/colipase secretion, compensating the impaired lipolysis by the added compound. The animals also had an elevated CCK secretion. The satiety for fat may be the consequence of elevated CCK and procolipase/enterostatin levels. We conclude that compounds can be found that delay intestinal fat digestion and control high-fat food intake through the release of satiety signals, without causing steatorrhea. The absence of steatorrhea makes such compounds advantageous over lipase inhibitors in the treatment of obesity.}}, author = {{Mei, Jie and Lindqvist, Andreas and Krabisch, Lennart and Rehfeld, Jens F. and Erlanson-Albertsson, Charlotte}}, issn = {{1873-507X}}, keywords = {{enterostatin; high-fat food intake; satiety; blood lipids; fecal fat; lipase; CCK; inhibitor}}, language = {{eng}}, number = {{4}}, pages = {{563--568}}, publisher = {{Elsevier}}, series = {{Physiology & Behavior}}, title = {{Appetite suppression through delayed fat digestion}}, url = {{http://dx.doi.org/10.1016/j.physbeh.2006.07.020}}, doi = {{10.1016/j.physbeh.2006.07.020}}, volume = {{89}}, year = {{2006}}, }