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Appetite suppression through delayed fat digestion

Mei, Jie LU ; Lindqvist, Andreas LU ; Krabisch, Lennart LU ; Rehfeld, Jens F. and Erlanson-Albertsson, Charlotte LU (2006) In Physiology & Behavior 89(4). p.563-568
Abstract
High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancreatic lipase/colipase secretion, compensating the impaired lipolysis by the added compound. The animals also had an elevated CCK secretion. The satiety for fat may be the consequence of elevated CCK and procolipase/enterostatin levels. We conclude that compounds can be found that delay intestinal fat... (More)
High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancreatic lipase/colipase secretion, compensating the impaired lipolysis by the added compound. The animals also had an elevated CCK secretion. The satiety for fat may be the consequence of elevated CCK and procolipase/enterostatin levels. We conclude that compounds can be found that delay intestinal fat digestion and control high-fat food intake through the release of satiety signals, without causing steatorrhea. The absence of steatorrhea makes such compounds advantageous over lipase inhibitors in the treatment of obesity. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
enterostatin, high-fat food intake, satiety, blood lipids, fecal fat, lipase, CCK, inhibitor
in
Physiology & Behavior
volume
89
issue
4
pages
563 - 568
publisher
Elsevier
external identifiers
  • wos:000242539600016
  • scopus:33750968773
  • pmid:16952381
ISSN
1873-507X
DOI
10.1016/j.physbeh.2006.07.020
language
English
LU publication?
yes
id
3932f424-1d6b-44dd-bc04-abe2c92c34ef (old id 683561)
date added to LUP
2016-04-01 16:20:09
date last changed
2022-01-28 19:01:16
@article{3932f424-1d6b-44dd-bc04-abe2c92c34ef,
  abstract     = {{High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancreatic lipase/colipase secretion, compensating the impaired lipolysis by the added compound. The animals also had an elevated CCK secretion. The satiety for fat may be the consequence of elevated CCK and procolipase/enterostatin levels. We conclude that compounds can be found that delay intestinal fat digestion and control high-fat food intake through the release of satiety signals, without causing steatorrhea. The absence of steatorrhea makes such compounds advantageous over lipase inhibitors in the treatment of obesity.}},
  author       = {{Mei, Jie and Lindqvist, Andreas and Krabisch, Lennart and Rehfeld, Jens F. and Erlanson-Albertsson, Charlotte}},
  issn         = {{1873-507X}},
  keywords     = {{enterostatin; high-fat food intake; satiety; blood lipids; fecal fat; lipase; CCK; inhibitor}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{563--568}},
  publisher    = {{Elsevier}},
  series       = {{Physiology & Behavior}},
  title        = {{Appetite suppression through delayed fat digestion}},
  url          = {{http://dx.doi.org/10.1016/j.physbeh.2006.07.020}},
  doi          = {{10.1016/j.physbeh.2006.07.020}},
  volume       = {{89}},
  year         = {{2006}},
}