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T wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage.

Demidova, Marina LU ; Martín-Yebra, Alba; Martínez, Juan Pablo; Monasterio, Violeta; Koul, Sasha LU ; vanderPals, Jesper LU ; Romero, Daniel; Laguna, Pablo; Erlinge, David LU and Platonov, Pyotr LU (2013) In Journal of Electrocardiology 46(3). p.263-269
Abstract
BACKGROUND: T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction. METHODS: In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively. RESULTS: TWA appeared at 7.2±4.5minutes of occlusion, reached its maximum at 12.7±6.3 and lasted until... (More)
BACKGROUND: T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction. METHODS: In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively. RESULTS: TWA appeared at 7.2±4.5minutes of occlusion, reached its maximum at 12.7±6.3 and lasted until 26.5±9.2minutes. The maximal level of TWA was associated with both MaR (r=0.499, p=0.035) and IS (r=0.65, p=0.004). CONCLUSION: TWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Electrocardiology
volume
46
issue
3
pages
263 - 269
publisher
Elsevier
external identifiers
  • wos:000318457600012
  • pmid:23522735
  • scopus:84876675340
ISSN
1532-8430
DOI
10.1016/j.jelectrocard.2013.03.001
language
English
LU publication?
yes
id
6875ac1a-a608-4fdf-a74d-c6d65c477318 (old id 3627759)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23522735?dopt=Abstract
date added to LUP
2013-04-07 16:35:42
date last changed
2019-02-20 01:13:09
@article{6875ac1a-a608-4fdf-a74d-c6d65c477318,
  abstract     = {BACKGROUND: T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction. METHODS: In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively. RESULTS: TWA appeared at 7.2±4.5minutes of occlusion, reached its maximum at 12.7±6.3 and lasted until 26.5±9.2minutes. The maximal level of TWA was associated with both MaR (r=0.499, p=0.035) and IS (r=0.65, p=0.004). CONCLUSION: TWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings.},
  author       = {Demidova, Marina and Martín-Yebra, Alba and Martínez, Juan Pablo and Monasterio, Violeta and Koul, Sasha and vanderPals, Jesper and Romero, Daniel and Laguna, Pablo and Erlinge, David and Platonov, Pyotr},
  issn         = {1532-8430},
  language     = {eng},
  number       = {3},
  pages        = {263--269},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {T wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage.},
  url          = {http://dx.doi.org/10.1016/j.jelectrocard.2013.03.001},
  volume       = {46},
  year         = {2013},
}