Advanced

A 59-kd renal antigen as a new target for rapidly progressive glomerulonephritis

Audard, Vincent; Hellmark, Thomas LU ; El Karoui, Khalil; Noel, Laure Helene; Pardon, Agathe; Desvaux, Dominique; Touchard, Guy; Remy, Philippe; Lang, Philippe and Sahali, Djillali (2007) In American Journal of Kidney Diseases 49(5). p.710-716
Abstract
Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
goodpasture disease, anti-tubular basement membrane antibodies
in
American Journal of Kidney Diseases
volume
49
issue
5
pages
710 - 716
publisher
Elsevier
external identifiers
  • wos:000248570100021
  • scopus:34247530390
ISSN
1523-6838
DOI
10.1053/j.ajkd.2007.02.002
language
English
LU publication?
yes
id
2ece954e-48df-4d4a-b5aa-5e7867e62c58 (old id 689698)
date added to LUP
2007-12-07 11:14:40
date last changed
2017-01-01 04:37:05
@article{2ece954e-48df-4d4a-b5aa-5e7867e62c58,
  abstract     = {Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.},
  author       = {Audard, Vincent and Hellmark, Thomas and El Karoui, Khalil and Noel, Laure Helene and Pardon, Agathe and Desvaux, Dominique and Touchard, Guy and Remy, Philippe and Lang, Philippe and Sahali, Djillali},
  issn         = {1523-6838},
  keyword      = {goodpasture disease,anti-tubular basement membrane antibodies},
  language     = {eng},
  number       = {5},
  pages        = {710--716},
  publisher    = {Elsevier},
  series       = {American Journal of Kidney Diseases},
  title        = {A 59-kd renal antigen as a new target for rapidly progressive glomerulonephritis},
  url          = {http://dx.doi.org/10.1053/j.ajkd.2007.02.002},
  volume       = {49},
  year         = {2007},
}