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Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer

Sonestedt, Emily LU ; Gullberg, Bo LU and Wirfält, Elisabet LU (2007) In Public Health Nutrition 10(8). p.769-779
Abstract
Objective: Valid dietary data are essential when trying to identify whether or not one or more dietary exposures are responsible for disease. We examined diet composition in women who reported dietary change in the past compared with non-changers, and how the associations between dietary factors and postmenopausal breast cancer are influenced by dietary change, obesity status and misreporting of energy. Design: A population-based prospective cohort Study. Data were obtained by a diet history method, anthropometrical measurements and an extensive lifestyle questionnaire including items on past food habit change. Setting: The Malmo Diet and Cancer (MDC) study, conducted in Malmo, Sweden. Subjects: A subsample of 12 781 women from the MDC... (More)
Objective: Valid dietary data are essential when trying to identify whether or not one or more dietary exposures are responsible for disease. We examined diet composition in women who reported dietary change in the past compared with non-changers, and how the associations between dietary factors and postmenopausal breast cancer are influenced by dietary change, obesity status and misreporting of energy. Design: A population-based prospective cohort Study. Data were obtained by a diet history method, anthropometrical measurements and an extensive lifestyle questionnaire including items on past food habit change. Setting: The Malmo Diet and Cancer (MDC) study, conducted in Malmo, Sweden. Subjects: A subsample of 12 781 women from the MDC cohort recruited from 1991 to 1996. A total of 428 postmenopausal women were diagnosed with incident breast cancer, during 9.2 years of follow-up. Results: Past food habit changers reported healthier food habits and lower energy intake compared with non-changers, a finding that raises issues regarding possible reporting biases. When excluding diet changers, the trend of increased breast cancer risk across omega-6 fatty acid quintiles was stronger, and a tendency of decreased risk emerged for 'fruit, berries and vegetables'. When excluding individuals with non-adequate reports of energy intake, risk estimates were similar to that of the whole sample. In women with body mass index < 27kg m(-2) significant trends of increased breast cancer risk were seen for total fat and omega-6 fatty acids, and of decreased risk for 'fruit, berries and vegetables. Conclusions: This study indicates that both obesity and self-reported past food habit change may be important confounders of diet-breast cancer relationships. The study demonstrates that sensitivity analysis, through stratification, may facilitate interpretation of risk relationships and study results. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cohort studies, breast cancer, under-reporting, past food habit change, obesity, postmenopausal
in
Public Health Nutrition
volume
10
issue
8
pages
769 - 779
publisher
Cambridge University Press
external identifiers
  • wos:000248451500005
  • scopus:34447121243
ISSN
1475-2727
DOI
10.1017/S1368980007246646
language
English
LU publication?
yes
id
fe8a2b9b-bfaf-483b-8960-3094f6d0d946 (old id 689799)
date added to LUP
2008-01-03 08:37:24
date last changed
2017-07-23 04:35:28
@article{fe8a2b9b-bfaf-483b-8960-3094f6d0d946,
  abstract     = {Objective: Valid dietary data are essential when trying to identify whether or not one or more dietary exposures are responsible for disease. We examined diet composition in women who reported dietary change in the past compared with non-changers, and how the associations between dietary factors and postmenopausal breast cancer are influenced by dietary change, obesity status and misreporting of energy. Design: A population-based prospective cohort Study. Data were obtained by a diet history method, anthropometrical measurements and an extensive lifestyle questionnaire including items on past food habit change. Setting: The Malmo Diet and Cancer (MDC) study, conducted in Malmo, Sweden. Subjects: A subsample of 12 781 women from the MDC cohort recruited from 1991 to 1996. A total of 428 postmenopausal women were diagnosed with incident breast cancer, during 9.2 years of follow-up. Results: Past food habit changers reported healthier food habits and lower energy intake compared with non-changers, a finding that raises issues regarding possible reporting biases. When excluding diet changers, the trend of increased breast cancer risk across omega-6 fatty acid quintiles was stronger, and a tendency of decreased risk emerged for 'fruit, berries and vegetables'. When excluding individuals with non-adequate reports of energy intake, risk estimates were similar to that of the whole sample. In women with body mass index &lt; 27kg m(-2) significant trends of increased breast cancer risk were seen for total fat and omega-6 fatty acids, and of decreased risk for 'fruit, berries and vegetables. Conclusions: This study indicates that both obesity and self-reported past food habit change may be important confounders of diet-breast cancer relationships. The study demonstrates that sensitivity analysis, through stratification, may facilitate interpretation of risk relationships and study results.},
  author       = {Sonestedt, Emily and Gullberg, Bo and Wirfält, Elisabet},
  issn         = {1475-2727},
  keyword      = {cohort studies,breast cancer,under-reporting,past food habit change,obesity,postmenopausal},
  language     = {eng},
  number       = {8},
  pages        = {769--779},
  publisher    = {Cambridge University Press},
  series       = {Public Health Nutrition},
  title        = {Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer},
  url          = {http://dx.doi.org/10.1017/S1368980007246646},
  volume       = {10},
  year         = {2007},
}