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Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort

Botteri, E. ; Ferrari, P. ; Roswall, N. ; Tjønneland, A. ; Hjartåker, A. ; Huerta, J. M. ; Fortner, R. T. ; Trichopoulou, A. ; Karakatsani, A. and La Vecchia, C. , et al. (2017) In International Journal of Cancer 141(10). p.1963-1970
Abstract

Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35–70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits). Baseline alcohol intake was associated with a statistically nonsignificant increased risk of UCC (HR 1.03; 95% confidence interval (CI)... (More)

Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35–70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits). Baseline alcohol intake was associated with a statistically nonsignificant increased risk of UCC (HR 1.03; 95% confidence interval (CI) 1.00–1.06 for each additional 12 g/day). HR in smokers was 1.04 (95% CI 1.01–1.07). Men reporting high baseline intakes of alcohol (>96 g/day) had an increased risk of UCC (HR 1.57; 95% CI 1.03–2.40) compared to those reporting moderate intakes (<6 g/day), but no dose–response relationship emerged. In men, an increased risk of aggressive forms of UCC was observed even at lower doses (>6 to 24 g/day). Average lifelong alcohol intake was not associated with the risk of UCC, however intakes of spirits > 24 g/day were associated with an increased risk of UCC in men (1.38; 95% CI 1.01–1.91) and smokers (1.39; 95% CI 1.01–1.92), compared to moderate intakes. We found no association between alcohol and UCC in women and never smokers. In conclusion, we observed some associations between alcohol and UCC in men and in smokers, possibly because of residual confounding by tobacco smoking.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alcohol, alcoholic beverages, bladder cancer, cancer stage, cohort study
in
International Journal of Cancer
volume
141
issue
10
pages
8 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85026435547
  • pmid:28722206
  • wos:000411057400003
ISSN
0020-7136
DOI
10.1002/ijc.30894
language
English
LU publication?
yes
id
6fd17c77-029a-4ad1-887e-d2e396401cf9
date added to LUP
2017-11-22 08:57:06
date last changed
2024-05-13 01:05:51
@article{6fd17c77-029a-4ad1-887e-d2e396401cf9,
  abstract     = {{<p>Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35–70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits). Baseline alcohol intake was associated with a statistically nonsignificant increased risk of UCC (HR 1.03; 95% confidence interval (CI) 1.00–1.06 for each additional 12 g/day). HR in smokers was 1.04 (95% CI 1.01–1.07). Men reporting high baseline intakes of alcohol (&gt;96 g/day) had an increased risk of UCC (HR 1.57; 95% CI 1.03–2.40) compared to those reporting moderate intakes (&lt;6 g/day), but no dose–response relationship emerged. In men, an increased risk of aggressive forms of UCC was observed even at lower doses (&gt;6 to 24 g/day). Average lifelong alcohol intake was not associated with the risk of UCC, however intakes of spirits &gt; 24 g/day were associated with an increased risk of UCC in men (1.38; 95% CI 1.01–1.91) and smokers (1.39; 95% CI 1.01–1.92), compared to moderate intakes. We found no association between alcohol and UCC in women and never smokers. In conclusion, we observed some associations between alcohol and UCC in men and in smokers, possibly because of residual confounding by tobacco smoking.</p>}},
  author       = {{Botteri, E. and Ferrari, P. and Roswall, N. and Tjønneland, A. and Hjartåker, A. and Huerta, J. M. and Fortner, R. T. and Trichopoulou, A. and Karakatsani, A. and La Vecchia, C. and Pala, V. and Perez-Cornago, A. and Sonestedt, E. and Liedberg, F. and Overvad, K. and Sánchez, M. J. and Gram, I. T. and Stepien, M. and Trijsburg, L. and Börje, L. and Johansson, M. and Kühn, T. and Panico, S. and Tumino, R. and Bueno-de-Mesquita, H. Bas and Weiderpass, E.}},
  issn         = {{0020-7136}},
  keywords     = {{alcohol; alcoholic beverages; bladder cancer; cancer stage; cohort study}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{10}},
  pages        = {{1963--1970}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort}},
  url          = {{http://dx.doi.org/10.1002/ijc.30894}},
  doi          = {{10.1002/ijc.30894}},
  volume       = {{141}},
  year         = {{2017}},
}