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Models for control of intravenous anesthesia

Soltesz, Kristian LU orcid ; van Heusden, Klaske and Dumont, Guy A. (2020) p.119-166
Abstract
Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through the pharmacokinetics (PK) and pharmacodynamics (PD) of the patient. This chapter gives an introduction to PKPD modeling in automated anesthesia management, intended to be accessible to both anesthesiology and (control) engineering researchers. The following topics are discussed: the role of modeling; the classic PKPD structure used in clinical... (More)
Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through the pharmacokinetics (PK) and pharmacodynamics (PD) of the patient. This chapter gives an introduction to PKPD modeling in automated anesthesia management, intended to be accessible to both anesthesiology and (control) engineering researchers. The following topics are discussed: the role of modeling; the classic PKPD structure used in clinical pharmacology; anesthesia modeling and identification for closed-loop control; inter-patient variability and model uncertainty; disturbance, noise and equipment models. The chapter emphasizes electroencephalogram-guided control of propofol. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Automated drug delivery in anesthesia
pages
48 pages
publisher
Elsevier
external identifiers
  • scopus:85092226777
ISBN
9780128159767
9780128159750
DOI
10.1016/B978-0-12-815975-0.00010-2
project
Anesthesia in Closed Loop
Hemodynamic Stabilization
language
English
LU publication?
yes
id
718f3ce7-12d3-447b-9e8b-9f08438d03cc
date added to LUP
2019-08-13 09:03:16
date last changed
2024-04-08 00:43:17
@inbook{718f3ce7-12d3-447b-9e8b-9f08438d03cc,
  abstract     = {{Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through the pharmacokinetics (PK) and pharmacodynamics (PD) of the patient. This chapter gives an introduction to PKPD modeling in automated anesthesia management, intended to be accessible to both anesthesiology and (control) engineering researchers. The following topics are discussed: the role of modeling; the classic PKPD structure used in clinical pharmacology; anesthesia modeling and identification for closed-loop control; inter-patient variability and model uncertainty; disturbance, noise and equipment models. The chapter emphasizes electroencephalogram-guided control of propofol.}},
  author       = {{Soltesz, Kristian and van Heusden, Klaske and Dumont, Guy A.}},
  booktitle    = {{Automated drug delivery in anesthesia}},
  isbn         = {{9780128159767}},
  language     = {{eng}},
  pages        = {{119--166}},
  publisher    = {{Elsevier}},
  title        = {{Models for control of intravenous anesthesia}},
  url          = {{https://lup.lub.lu.se/search/files/83468216/soltesz20c.pdf}},
  doi          = {{10.1016/B978-0-12-815975-0.00010-2}},
  year         = {{2020}},
}