Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Familial associations for rheumatoid autoimmune diseases

Thomsen, Hauke LU orcid ; Li, Xinjun LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU and Hemminki, Kari LU (2020) In Rheumatology Advances in Practice 4(2).
Abstract

Objective: Previous studies have shown a familial component in RA and in some other rheumatic autoimmune diseases (RAIDs), but because of the different study designs the risk estimates for familial risks differ extensively. The objective of this study is to identify familial components for RAIDs. Methods: We collected data on patients diagnosed in Swedish hospitals with RA, AS, PM/DM, SS, SLE and SSc (and scleroderma) and calculated familial standardized incidence ratios (SIRs) for each of these (concordant) and between them (discordant). Results: The combined number of RAID patients in the offspring population (for whom SIRs were calculated) was 71 544, and in the whole population the number was 152 714, accounting for 19.8% of all... (More)

Objective: Previous studies have shown a familial component in RA and in some other rheumatic autoimmune diseases (RAIDs), but because of the different study designs the risk estimates for familial risks differ extensively. The objective of this study is to identify familial components for RAIDs. Methods: We collected data on patients diagnosed in Swedish hospitals with RA, AS, PM/DM, SS, SLE and SSc (and scleroderma) and calculated familial standardized incidence ratios (SIRs) for each of these (concordant) and between them (discordant). Results: The combined number of RAID patients in the offspring population (for whom SIRs were calculated) was 71 544, and in the whole population the number was 152 714, accounting for 19.8% of all autoimmune diseases in Sweden. AS showed the highest concordant familial risk of 18.42, followed by SLE (14.04), SS (8.63), SSc (4.50), PM/DM (4.03) and RA (3.03). There was no sex difference in SIRs. Risks for AS and SLE were 80.28 and 19.53 for persons whose parents and siblings were affected. Discordant risks were far lower than concordant risks, but they were significant for RA with all the other five RAIDs, for SLE and SSc with four RAIDs, for AS and SS with three RAIDs and for PM/DM with two RAIDs, attesting to extensive polyautoimmunity between RAIDs. Conclusion: The derived familial risks in this nationwide family study on medically diagnosed RAID are compatible with emerging evidence on the polygenic background of these complex diseases. Novel genetic pathways offer new therapeutic targets that alleviate disease onset optimally in high-risk familial patients and others.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ankylosing spondylitis, Discordant risks, Lupus, Polyautoimmunity, Rheumatoid arthritis, Sjögren's syndrome
in
Rheumatology Advances in Practice
volume
4
issue
2
article number
rkaa048
publisher
Oxford University Press
external identifiers
  • scopus:85100203116
  • scopus:85100203116
ISSN
2514-1775
DOI
10.1093/RAP/RKAA048
language
English
LU publication?
yes
id
719197bd-7bca-4577-8c01-ffb17ac32550
date added to LUP
2020-11-26 12:16:59
date last changed
2022-04-26 22:05:15
@article{719197bd-7bca-4577-8c01-ffb17ac32550,
  abstract     = {{<p>Objective: Previous studies have shown a familial component in RA and in some other rheumatic autoimmune diseases (RAIDs), but because of the different study designs the risk estimates for familial risks differ extensively. The objective of this study is to identify familial components for RAIDs. Methods: We collected data on patients diagnosed in Swedish hospitals with RA, AS, PM/DM, SS, SLE and SSc (and scleroderma) and calculated familial standardized incidence ratios (SIRs) for each of these (concordant) and between them (discordant). Results: The combined number of RAID patients in the offspring population (for whom SIRs were calculated) was 71 544, and in the whole population the number was 152 714, accounting for 19.8% of all autoimmune diseases in Sweden. AS showed the highest concordant familial risk of 18.42, followed by SLE (14.04), SS (8.63), SSc (4.50), PM/DM (4.03) and RA (3.03). There was no sex difference in SIRs. Risks for AS and SLE were 80.28 and 19.53 for persons whose parents and siblings were affected. Discordant risks were far lower than concordant risks, but they were significant for RA with all the other five RAIDs, for SLE and SSc with four RAIDs, for AS and SS with three RAIDs and for PM/DM with two RAIDs, attesting to extensive polyautoimmunity between RAIDs. Conclusion: The derived familial risks in this nationwide family study on medically diagnosed RAID are compatible with emerging evidence on the polygenic background of these complex diseases. Novel genetic pathways offer new therapeutic targets that alleviate disease onset optimally in high-risk familial patients and others. </p>}},
  author       = {{Thomsen, Hauke and Li, Xinjun and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Hemminki, Kari}},
  issn         = {{2514-1775}},
  keywords     = {{Ankylosing spondylitis; Discordant risks; Lupus; Polyautoimmunity; Rheumatoid arthritis; Sjögren's syndrome}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Oxford University Press}},
  series       = {{Rheumatology Advances in Practice}},
  title        = {{Familial associations for rheumatoid autoimmune diseases}},
  url          = {{http://dx.doi.org/10.1093/RAP/RKAA048}},
  doi          = {{10.1093/RAP/RKAA048}},
  volume       = {{4}},
  year         = {{2020}},
}