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Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition.

Leenders, Max; Siersema, Peter D; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Boutron-Ruault, Marie-Christine; Bastide, Nadia; Fagherazzi, Guy; Katzke, Verena and Kühn, Tilman, et al. (2015) In International Journal of Cancer 137(11). p.2705-2714
Abstract
Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of nine years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of thirteen years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported... (More)
Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of nine years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of thirteen years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95%CI 0.75-1.01, P for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than ten years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but seems unlikely. This article is protected by copyright. All rights reserved. (Less)
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International Journal of Cancer
volume
137
issue
11
pages
2705 - 2714
publisher
John Wiley & Sons
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  • pmid:26077137
  • wos:000362843000016
  • scopus:84941735724
ISSN
0020-7136
DOI
10.1002/ijc.29640
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English
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yes
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2a556965-3c9d-499e-950e-c40d0173c0a6 (old id 7476764)
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http://www.ncbi.nlm.nih.gov/pubmed/26077137?dopt=Abstract
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2015-07-12 17:50:21
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@article{2a556965-3c9d-499e-950e-c40d0173c0a6,
  abstract     = {Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of nine years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of thirteen years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95%CI 0.75-1.01, P for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than ten years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but seems unlikely. This article is protected by copyright. All rights reserved.},
  author       = {Leenders, Max and Siersema, Peter D and Overvad, Kim and Tjønneland, Anne and Olsen, Anja and Boutron-Ruault, Marie-Christine and Bastide, Nadia and Fagherazzi, Guy and Katzke, Verena and Kühn, Tilman and Boeing, Heiner and Aleksandrova, Krasimira and Trichopoulou, Antonia and Lagiou, Pagona and Klinaki, Eleni and Masala, Giovanna and Grioni, Sara and De Magistris, Maria Santucci and Tumino, Rosario and Ricceri, Fulvio and Peeters, Petra H M and Lund, Eiliv and Skeie, Guri and Weiderpass, Elisabete and Quirós, J Ramón and Agudo, Antonio and Sánchez, María-José and Dorronsoro, Miren and Navarro, Carmen and Ardanaz, Eva and Ohlsson, Bodil and Jirström, Karin and Van Guelpen, Bethany and Wennberg, Maria and Khaw, Kay-Tee and Wareham, Nick and Key, Timothy J and Romieu, Isabelle and Huybrechts, Inge and Cross, Amanda J and Murphy, Neil and Riboli, Elio and Bueno-de-Mesquita, H Bas},
  issn         = {0020-7136},
  language     = {eng},
  number       = {11},
  pages        = {2705--2714},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition.},
  url          = {http://dx.doi.org/10.1002/ijc.29640},
  volume       = {137},
  year         = {2015},
}