Esophageal and gastric dysmotilities are associated with altered glucose homeostasis and plasma levels of incretins and leptin
(2016) In Review of Diabetic Studies 13(1). p.79-90- Abstract
BACKGROUND: Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucosedependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis, food intake, and gastric emptying. AIM: The aim was to investigate associations between diabetes complications and glucose homeostasis and plasma levels of GIP, GLP-1, and leptin. METHODS: Sixteen diabetes patients (seven men) were examined with gastric emptying scintigraphy and 72-h continuous subcutaneous glucose monitoring, 14 with the deep-breathing test, and 12 with esophageal manometry. A fiber-rich breakfast was given during the second day of glucose registration. Blood samples were taken 10 min and right before... (More)
BACKGROUND: Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucosedependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis, food intake, and gastric emptying. AIM: The aim was to investigate associations between diabetes complications and glucose homeostasis and plasma levels of GIP, GLP-1, and leptin. METHODS: Sixteen diabetes patients (seven men) were examined with gastric emptying scintigraphy and 72-h continuous subcutaneous glucose monitoring, 14 with the deep-breathing test, and 12 with esophageal manometry. A fiber-rich breakfast was given during the second day of glucose registration. Blood samples were taken 10 min and right before a fat-rich breakfast, as well as 10, 20, 30, 45, 60, 90, 120, 150, and 180 min afterwards. 20 healthy volunteers acted as controls. Plasma was analyzed regarding GIP, GLP-1, and leptin by Luminex. RESULTS: Gastroparesis lowered maximal concentration (c-max) (p = 0.003) and total area under the curve (tAUC) (p = 0.019) of glucose levels as well as d-min (p = 0.043) of leptin levels. It tended to lower baseline (p = 0.073), c-max (p = 0.066), change from baseline (dmax) (p = 0.073), and tAUC (p = 0.093) of GLP-1 concentrations. Esophageal dysmotility tended to lower tAUC of glucose levels (p = 0.063), and c-min (p = 0.065) and tAUC (p = 0.063) of leptin levels. Diabetes patients had a higher baseline concentration of glucose (p = 0.013), GIP (p = 0.023), and leptin (p = 0.019) compared with healthy subjects. CONCLUSIONS: Gastric and esophageal dysmotility are associated with both lesser increases in postprandial glucose elevations and decreased postprandial changes in GLP-1 and leptin.
(Less)
- author
- Hammersjö, Rebecka ; Roth, Bodil LU ; Höglund, Peter LU and Ohlsson, Bodil LU
- organization
- publishing date
- 2016-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autonomic neuropathy, Diabetes mellitus, Esophageal dysmotility, Gastroparesis, Incretins, Leptin
- in
- Review of Diabetic Studies
- volume
- 13
- issue
- 1
- pages
- 79 - 90
- publisher
- Lab and Life Press
- external identifiers
-
- scopus:85006821270
- pmid:27563696
- ISSN
- 1613-6071
- DOI
- 10.1900/RDS.2016.13.79
- language
- English
- LU publication?
- yes
- id
- 76ff914f-8570-4634-adf9-663b48e3523f
- date added to LUP
- 2017-01-19 15:27:49
- date last changed
- 2025-04-04 15:21:09
@article{76ff914f-8570-4634-adf9-663b48e3523f,
abstract = {{<p>BACKGROUND: Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucosedependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis, food intake, and gastric emptying. AIM: The aim was to investigate associations between diabetes complications and glucose homeostasis and plasma levels of GIP, GLP-1, and leptin. METHODS: Sixteen diabetes patients (seven men) were examined with gastric emptying scintigraphy and 72-h continuous subcutaneous glucose monitoring, 14 with the deep-breathing test, and 12 with esophageal manometry. A fiber-rich breakfast was given during the second day of glucose registration. Blood samples were taken 10 min and right before a fat-rich breakfast, as well as 10, 20, 30, 45, 60, 90, 120, 150, and 180 min afterwards. 20 healthy volunteers acted as controls. Plasma was analyzed regarding GIP, GLP-1, and leptin by Luminex. RESULTS: Gastroparesis lowered maximal concentration (c-max) (p = 0.003) and total area under the curve (tAUC) (p = 0.019) of glucose levels as well as d-min (p = 0.043) of leptin levels. It tended to lower baseline (p = 0.073), c-max (p = 0.066), change from baseline (dmax) (p = 0.073), and tAUC (p = 0.093) of GLP-1 concentrations. Esophageal dysmotility tended to lower tAUC of glucose levels (p = 0.063), and c-min (p = 0.065) and tAUC (p = 0.063) of leptin levels. Diabetes patients had a higher baseline concentration of glucose (p = 0.013), GIP (p = 0.023), and leptin (p = 0.019) compared with healthy subjects. CONCLUSIONS: Gastric and esophageal dysmotility are associated with both lesser increases in postprandial glucose elevations and decreased postprandial changes in GLP-1 and leptin.</p>}},
author = {{Hammersjö, Rebecka and Roth, Bodil and Höglund, Peter and Ohlsson, Bodil}},
issn = {{1613-6071}},
keywords = {{Autonomic neuropathy; Diabetes mellitus; Esophageal dysmotility; Gastroparesis; Incretins; Leptin}},
language = {{eng}},
month = {{03}},
number = {{1}},
pages = {{79--90}},
publisher = {{Lab and Life Press}},
series = {{Review of Diabetic Studies}},
title = {{Esophageal and gastric dysmotilities are associated with altered glucose homeostasis and plasma levels of incretins and leptin}},
url = {{http://dx.doi.org/10.1900/RDS.2016.13.79}},
doi = {{10.1900/RDS.2016.13.79}},
volume = {{13}},
year = {{2016}},
}