Advanced

Body iron status and gastric cancer risk in the EURGAST study.

Fonseca-Nunes, Ana; Agudo, Antonio; Aranda, Núria; Arija, Victoria; Cross, Amanda J; Molina, Esther; Sanchez, Maria Jose; Bueno-de-Mesquita, Bas; Siersema, Peter and Weiderpass, Elisabete, et al. (2015) In International Journal of Cancer 137(12). p.2904-2914
Abstract
Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence... (More)
Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 = 0.80, 95% CI = 0.72-0.88; OR10%increment = 0.87, 95% CI = 0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity = 0.04 and TS had a p for heterogeneity = 0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl = 1.13, 95% CI = 1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity = 0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
137
issue
12
pages
2904 - 2914
publisher
John Wiley & Sons
external identifiers
  • pmid:26135329
  • wos:000362843300017
  • scopus:84943665092
ISSN
0020-7136
DOI
10.1002/ijc.29669
language
English
LU publication?
yes
id
c0259c8e-23de-4dd8-9ace-4068b539d1cd (old id 7750932)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26135329?dopt=Abstract
date added to LUP
2015-08-04 21:06:58
date last changed
2017-07-23 03:26:11
@article{c0259c8e-23de-4dd8-9ace-4068b539d1cd,
  abstract     = {Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 = 0.80, 95% CI = 0.72-0.88; OR10%increment = 0.87, 95% CI = 0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity = 0.04 and TS had a p for heterogeneity = 0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl = 1.13, 95% CI = 1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity = 0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis.},
  author       = {Fonseca-Nunes, Ana and Agudo, Antonio and Aranda, Núria and Arija, Victoria and Cross, Amanda J and Molina, Esther and Sanchez, Maria Jose and Bueno-de-Mesquita, Bas and Siersema, Peter and Weiderpass, Elisabete and Krogh, Vittorio and Mattiello, Amalia and Tumino, Rosario and Saieva, Calogero and Naccarati, Alessio and Ohlsson, Bodil and Sjöberg, Klas and Boutron-Ruault, Marie-Christine and Cadeau, Claire and Fagherazzi, Guy and Boeing, Heiner and Steffen, Annika and Kühn, Tilman and Katzke, Verena and Tjønneland, Anne and Olsen, Anja and Khaw, Kay-Tee and Wareham, Nick and Key, Tim and Lu, Yunxia and Riboli, Elio and Peeters, Petra H and Gavrila, Diana and Dorronsoro, Miren and Quirós, José Ramón and Barricarte, Aurelio and Jenab, Mazda and Zamora-Ros, Raúl and Freisling, Heinz and Trichopoulou, Antonia and Lagiou, Pagona and Bamia, Christina and Jakszyn, Paula},
  issn         = {0020-7136},
  language     = {eng},
  number       = {12},
  pages        = {2904--2914},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Body iron status and gastric cancer risk in the EURGAST study.},
  url          = {http://dx.doi.org/10.1002/ijc.29669},
  volume       = {137},
  year         = {2015},
}