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Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Agardh, Elisabet LU ; Lundstig, Annika LU ; Perfilyev, Alexander LU ; Volkov, Petr LU ; Freiburghaus, Tove LU ; Lindholm, Eero LU ; Rönn, Tina LU ; Agardh, Carl-David LU and Ling, Charlotte LU (2015) In BMC Medicine 13(182).
Abstract
Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Medicine
volume
13
issue
182
publisher
BioMed Central
external identifiers
  • pmid:26248552
  • wos:000359149600001
  • scopus:84938566124
ISSN
1741-7015
DOI
10.1186/s12916-015-0421-5
language
English
LU publication?
yes
id
98e46881-2748-40a0-a207-6ac49b962f46 (old id 7844528)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26248552?dopt=Abstract
date added to LUP
2015-09-05 15:32:13
date last changed
2017-11-05 03:51:33
@article{98e46881-2748-40a0-a207-6ac49b962f46,
  abstract     = {Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).},
  author       = {Agardh, Elisabet and Lundstig, Annika and Perfilyev, Alexander and Volkov, Petr and Freiburghaus, Tove and Lindholm, Eero and Rönn, Tina and Agardh, Carl-David and Ling, Charlotte},
  issn         = {1741-7015},
  language     = {eng},
  number       = {182},
  publisher    = {BioMed Central},
  series       = {BMC Medicine},
  title        = {Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.},
  url          = {http://dx.doi.org/10.1186/s12916-015-0421-5},
  volume       = {13},
  year         = {2015},
}