Acute pancreatitis - from cellular signalling to complicated clinical course.
(2007) In HPB 9(6). p.414-420- Abstract
- Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve outcome, diagnostic possibilities, their indications and optimal timing, and the systemic inflammatory reaction (systemic inflammatory response syndrome - SIRS) and its effect on the concomitant course of the disease and potential development of organ failure. The role of the gut has been suggested to be important in severe AP, but has recently been... (More)
- Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve outcome, diagnostic possibilities, their indications and optimal timing, and the systemic inflammatory reaction (systemic inflammatory response syndrome - SIRS) and its effect on the concomitant course of the disease and potential development of organ failure. The role of the gut has been suggested to be important in severe AP, but has recently been somewhat questioned. Despite extensive research, pharmacological and medical intervention of proven clinical value is scarce. Various aspects on surgical interventions, including endoscopic sphincterotomy, cholecystectomy and necrosectomy, as regards indications and timing, will be reviewed. Last, but not least, are the management of late complications and long-term outcome for patients with especially severe AP. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1052397
- author
- Andersson, Roland LU ; Andersson, Bodil LU ; Andersson, Ellen LU ; Axelsson, Jakob B LU ; Eckerwall, Gunilla LU and Tingstedt, Bobby LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- HPB
- volume
- 9
- issue
- 6
- pages
- 414 - 420
- publisher
- Elsevier
- external identifiers
-
- pmid:18345287
- scopus:36749022215
- pmid:18345287
- ISSN
- 1477-2574
- DOI
- 10.1080/13651820701713766
- language
- English
- LU publication?
- yes
- id
- 78c75b6a-bfc8-4372-a15a-d9028f875f6d (old id 1052397)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18345287?dopt=Abstract
- date added to LUP
- 2016-04-04 08:03:26
- date last changed
- 2022-01-29 02:59:49
@article{78c75b6a-bfc8-4372-a15a-d9028f875f6d, abstract = {{Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve outcome, diagnostic possibilities, their indications and optimal timing, and the systemic inflammatory reaction (systemic inflammatory response syndrome - SIRS) and its effect on the concomitant course of the disease and potential development of organ failure. The role of the gut has been suggested to be important in severe AP, but has recently been somewhat questioned. Despite extensive research, pharmacological and medical intervention of proven clinical value is scarce. Various aspects on surgical interventions, including endoscopic sphincterotomy, cholecystectomy and necrosectomy, as regards indications and timing, will be reviewed. Last, but not least, are the management of late complications and long-term outcome for patients with especially severe AP.}}, author = {{Andersson, Roland and Andersson, Bodil and Andersson, Ellen and Axelsson, Jakob B and Eckerwall, Gunilla and Tingstedt, Bobby}}, issn = {{1477-2574}}, language = {{eng}}, number = {{6}}, pages = {{414--420}}, publisher = {{Elsevier}}, series = {{HPB}}, title = {{Acute pancreatitis - from cellular signalling to complicated clinical course.}}, url = {{http://dx.doi.org/10.1080/13651820701713766}}, doi = {{10.1080/13651820701713766}}, volume = {{9}}, year = {{2007}}, }