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Effects of meal and incretins in the regulation of splanchnic blood flow

Koffert, Jukka; Honka, Henri; Teuho, Jarmo; Kauhanen, Saila; Hurme, Saija; Parkkola, Riitta; Oikonen, Vesa; Mari, Andrea; Lindqvist, Andreas LU and Wierup, Nils LU , et al. (2017) In Endocrine Connections 6(3). p.179-187
Abstract

Objective: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known. The aim of the present study was to evaluate the organ-specific changes in BF during a mixed-meal and incretin infusions. Design: A non-randomized intervention study of 10 healthy adults to study splanchnic BF regulation was performed. Methods: Effects of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) infusions and mixed-meal were tested in 10 healthy, glucose tolerant subjects using PET-MRI multimodal imaging technology. Intestinal and pancreatic BF... (More)

Objective: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known. The aim of the present study was to evaluate the organ-specific changes in BF during a mixed-meal and incretin infusions. Design: A non-randomized intervention study of 10 healthy adults to study splanchnic BF regulation was performed. Methods: Effects of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) infusions and mixed-meal were tested in 10 healthy, glucose tolerant subjects using PET-MRI multimodal imaging technology. Intestinal and pancreatic BF and blood volume (BV) were measured with 15O-water and 15O-carbon monoxide, respectively. Results: Ingestion of a mixed-meal led to an increase in pancreatic and jejunal BF, whereas duodenal BF was unchanged. Infusion of GIP and GLP-1 reduced BF in the pancreas. However, GIP infusion doubled blood flow in the jejunum with no effect of GLP-1. Conclusion: Together, our data suggest that meal ingestion leads to increases in pancreatic BF accompanied by a GIP-mediated increase in jejunal but not duodenal blood flow.

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Contribution to journal
publication status
published
subject
keywords
Incretins, Meal ingestion, Splanchnic blood flow
in
Endocrine Connections
volume
6
issue
3
pages
9 pages
publisher
BioScientifica Ltd.
external identifiers
  • scopus:85032336324
  • wos:000404924700006
ISSN
2049-3614
DOI
10.1530/EC-17-0015
language
English
LU publication?
yes
id
7bfd5c70-8b0f-4d0d-a8e1-0209e84c5eb0
date added to LUP
2017-11-08 09:55:38
date last changed
2018-05-20 04:38:41
@article{7bfd5c70-8b0f-4d0d-a8e1-0209e84c5eb0,
  abstract     = {<p>Objective: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known. The aim of the present study was to evaluate the organ-specific changes in BF during a mixed-meal and incretin infusions. Design: A non-randomized intervention study of 10 healthy adults to study splanchnic BF regulation was performed. Methods: Effects of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) infusions and mixed-meal were tested in 10 healthy, glucose tolerant subjects using PET-MRI multimodal imaging technology. Intestinal and pancreatic BF and blood volume (BV) were measured with 15O-water and 15O-carbon monoxide, respectively. Results: Ingestion of a mixed-meal led to an increase in pancreatic and jejunal BF, whereas duodenal BF was unchanged. Infusion of GIP and GLP-1 reduced BF in the pancreas. However, GIP infusion doubled blood flow in the jejunum with no effect of GLP-1. Conclusion: Together, our data suggest that meal ingestion leads to increases in pancreatic BF accompanied by a GIP-mediated increase in jejunal but not duodenal blood flow.</p>},
  author       = {Koffert, Jukka and Honka, Henri and Teuho, Jarmo and Kauhanen, Saila and Hurme, Saija and Parkkola, Riitta and Oikonen, Vesa and Mari, Andrea and Lindqvist, Andreas and Wierup, Nils and Groop, Leif and Nuutila, Pirjo},
  issn         = {2049-3614},
  keyword      = {Incretins,Meal ingestion,Splanchnic blood flow},
  language     = {eng},
  number       = {3},
  pages        = {179--187},
  publisher    = {BioScientifica Ltd.},
  series       = {Endocrine Connections},
  title        = {Effects of meal and incretins in the regulation of splanchnic blood flow},
  url          = {http://dx.doi.org/10.1530/EC-17-0015},
  volume       = {6},
  year         = {2017},
}