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Non-invasive evaluation of the effect of metoprolol on the atrioventricular node during permanent atrial fibrillation

Corino, Valentina D.A. ; Sandberg, Frida LU ; Mainardi, Luca T. ; Ulimoen, Sara R. ; Enger, Steve ; Tveit, Arnljot ; Platonov, Pyotr G. LU and Sornmo, Leif LU (2014) 41st Computing in Cardiology Conference, CinC 2014 In Computing in Cardiology 41. p.889-892
Abstract

The aim of this study was to evaluate changes in AV nodal properties during administration of metoprolol, using a novel ECG-based method for parameter estimation. The AV nodal parameters account for the probability of an impulse not passing through the fast pathway, the absolute refractory periods of the slow and fast pathways (aRPs and aRPf), representing the functional refractory period, and related prolongation in the respective refractory periods. Twenty patients (age 71±8 years, 14 men) with permanent AF from the RATe control in Atrial Fibrillation (RATAF) database were included in this study. Recordings during baseline and metoprolol administration were analyzed. Furthermore, simulated RR series were generated mimicking metoprolol... (More)

The aim of this study was to evaluate changes in AV nodal properties during administration of metoprolol, using a novel ECG-based method for parameter estimation. The AV nodal parameters account for the probability of an impulse not passing through the fast pathway, the absolute refractory periods of the slow and fast pathways (aRPs and aRPf), representing the functional refractory period, and related prolongation in the respective refractory periods. Twenty patients (age 71±8 years, 14 men) with permanent AF from the RATe control in Atrial Fibrillation (RATAF) database were included in this study. Recordings during baseline and metoprolol administration were analyzed. Furthermore, simulated RR series were generated mimicking metoprolol administration. During metoprolol administration, aRP was significantly prolonged in both pathways (aRPs: 342±39 vs. 408±81 ms, p<0.001; aRPf: 432±74 vs. 527±83 ms, p<0.001). Similar results were found for the simulated RR series: both aRPs and aRPf were significantly prolonged with metoprolol. The AV nodal parameters reflect expected changes after metoprolol administration, i.e., a prolongation in functional refractory period. The simulations suggest that aRP may serve as an estimate of the functional refractory period.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
host publication
Computing in Cardiology 2014
series title
Computing in Cardiology
volume
41
edition
January
pages
4 pages
conference name
41st Computing in Cardiology Conference, CinC 2014
conference location
Cambridge, United States
conference dates
2014-09-07 - 2014-09-10
external identifiers
  • scopus:84931390788
ISSN
2325-8861
ISBN
978-1-4799-4347-0
978-1-4799-4346-3
DOI
10.1093/europace/euu246
language
English
LU publication?
yes
id
7d6f1173-749a-4b6f-8cb8-a13a319fef17
date added to LUP
2019-06-04 15:42:15
date last changed
2025-01-09 13:20:44
@inproceedings{7d6f1173-749a-4b6f-8cb8-a13a319fef17,
  abstract     = {{<p>The aim of this study was to evaluate changes in AV nodal properties during administration of metoprolol, using a novel ECG-based method for parameter estimation. The AV nodal parameters account for the probability of an impulse not passing through the fast pathway, the absolute refractory periods of the slow and fast pathways (aRPs and aRPf), representing the functional refractory period, and related prolongation in the respective refractory periods. Twenty patients (age 71±8 years, 14 men) with permanent AF from the RATe control in Atrial Fibrillation (RATAF) database were included in this study. Recordings during baseline and metoprolol administration were analyzed. Furthermore, simulated RR series were generated mimicking metoprolol administration. During metoprolol administration, aRP was significantly prolonged in both pathways (aRPs: 342±39 vs. 408±81 ms, p&lt;0.001; aRPf: 432±74 vs. 527±83 ms, p&lt;0.001). Similar results were found for the simulated RR series: both aRPs and aRPf were significantly prolonged with metoprolol. The AV nodal parameters reflect expected changes after metoprolol administration, i.e., a prolongation in functional refractory period. The simulations suggest that aRP may serve as an estimate of the functional refractory period.</p>}},
  author       = {{Corino, Valentina D.A. and Sandberg, Frida and Mainardi, Luca T. and Ulimoen, Sara R. and Enger, Steve and Tveit, Arnljot and Platonov, Pyotr G. and Sornmo, Leif}},
  booktitle    = {{Computing in Cardiology 2014}},
  isbn         = {{978-1-4799-4347-0}},
  issn         = {{2325-8861}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{889--892}},
  series       = {{Computing in Cardiology}},
  title        = {{Non-invasive evaluation of the effect of metoprolol on the atrioventricular node during permanent atrial fibrillation}},
  url          = {{http://dx.doi.org/10.1093/europace/euu246}},
  doi          = {{10.1093/europace/euu246}},
  volume       = {{41}},
  year         = {{2014}},
}