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Diverging temporal trends of human exposure to bisphenols and plastizisers, such as phthalates, caused by substitution of legacy EDCs?

Gyllenhammar, Irina; Glynn, Anders; Jönsson, Bo A LU ; Lindh, Christian H. LU ; Darnerud, Per Ola; Svensson, Kettil and Lignell, Sanna (2017) In Environmental Research 153. p.48-54
Abstract

Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides. The results showed downward trends of several phthalates... (More)

Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides. The results showed downward trends of several phthalates which are in the process of being regulated and phased out. Concomitantly, an increasing trend was seen for a metabolite of the phthalate replacer Di-iso-nonylcyclohexane 1,2-dicarboxylate (DiNCH). Bisphenol A (BPA) showed a downward trend, whereas bisphenol F, identified as one of the substitutes for BPA, showed an increasing trend. The decreasing trend of triclosan is likely due to declining use within the EU. Temporal trend studies of urine samples make it possible to investigate human exposure to rapidly metabolised substances and study how measures taken to regulate and replace problematic chemicals affect human exposure.

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publication status
published
subject
in
Environmental Research
volume
153
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:84999026132
  • wos:000392366500007
ISSN
0013-9351
DOI
10.1016/j.envres.2016.11.012
language
English
LU publication?
yes
id
7e1448c2-5c59-430c-96c5-d9b99c743cae
date added to LUP
2017-02-03 12:21:00
date last changed
2018-04-29 04:35:39
@article{7e1448c2-5c59-430c-96c5-d9b99c743cae,
  abstract     = {<p>Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides. The results showed downward trends of several phthalates which are in the process of being regulated and phased out. Concomitantly, an increasing trend was seen for a metabolite of the phthalate replacer Di-iso-nonylcyclohexane 1,2-dicarboxylate (DiNCH). Bisphenol A (BPA) showed a downward trend, whereas bisphenol F, identified as one of the substitutes for BPA, showed an increasing trend. The decreasing trend of triclosan is likely due to declining use within the EU. Temporal trend studies of urine samples make it possible to investigate human exposure to rapidly metabolised substances and study how measures taken to regulate and replace problematic chemicals affect human exposure.</p>},
  author       = {Gyllenhammar, Irina and Glynn, Anders and Jönsson, Bo A and Lindh, Christian H. and Darnerud, Per Ola and Svensson, Kettil and Lignell, Sanna},
  issn         = {0013-9351},
  language     = {eng},
  month        = {02},
  pages        = {48--54},
  publisher    = {Elsevier},
  series       = {Environmental Research},
  title        = {Diverging temporal trends of human exposure to bisphenols and plastizisers, such as phthalates, caused by substitution of legacy EDCs?},
  url          = {http://dx.doi.org/10.1016/j.envres.2016.11.012},
  volume       = {153},
  year         = {2017},
}