Synthesis of controlled size starch nanoparticles (SNPs)
Gutiérrez, G. ; Morán, D. ; Marefati, A. LU ; Purhagen, J. LU
; Rayner, M.
LU
and Matos, M.
LU
(2020)
In Carbohydrate Polymers
250.
- Abstract
Starch nanoparticles (SNPs) are a promising choice for the strategic development of new renewable and biodegradable nanomaterials for novel biomedical and pharmaceutical applications when loaded with antibiotics or with anticancer agents as target drug delivery systems. The final properties of the SNPs are strongly influenced by the synthesis method and conditions being a controlled and monodispersed size crucial for these applications. The aim of this work was to synthesize controlled size SNPs through nanoprecipitation and microemulsion methods by modifying main operating parameters regarding the effect of amylose and amylopectin ratio in maize starches. SNPs were characterized by size and shape. SNPs from 59 to 118 nm were obtained... (More)
Starch nanoparticles (SNPs) are a promising choice for the strategic development of new renewable and biodegradable nanomaterials for novel biomedical and pharmaceutical applications when loaded with antibiotics or with anticancer agents as target drug delivery systems. The final properties of the SNPs are strongly influenced by the synthesis method and conditions being a controlled and monodispersed size crucial for these applications. The aim of this work was to synthesize controlled size SNPs through nanoprecipitation and microemulsion methods by modifying main operating parameters regarding the effect of amylose and amylopectin ratio in maize starches. SNPs were characterized by size and shape. SNPs from 59 to 118 nm were obtained by the nanoprecipitation method, registering the higer values when surfactant was added to the aqueous phase. Microemulsion method led to 35−147 nm sizes observing a higher particle formation capacity. The composition of the maize used influenced the final particle size and shape.
(Less)
- author
- Gutiérrez, G.
; Morán, D.
; Marefati, A.
LU
; Purhagen, J.
LU
; Rayner, M.
LU
and Matos, M.
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Absolute ethanol (PubChem CID: 702), CTAB (PubChem CID: 5974), High amylose, Microemulsion, Nanoprecipitation, Size control, Sodium hydroxide (PubChem CID: 14798), Span 60 (PubChem CID: 3793749), Starch nanoparticles, Tween 20 (PubChem CID: 443314), Urea (PubChem CID: 1176), Waxy
- in
- Carbohydrate Polymers
- volume
- 250
- article number
- 116938
- publisher
- Elsevier
- external identifiers
-
- scopus:85089703992
- pmid:33049850
- ISSN
- 0144-8617
- DOI
- 10.1016/j.carbpol.2020.116938
- language
- English
- LU publication?
- yes
- id
- 7e3960fd-0eec-4712-9645-15473bbba6b2
- date added to LUP
- 2021-01-15 10:46:45
- date last changed
- 2024-06-14 08:03:18
@article{7e3960fd-0eec-4712-9645-15473bbba6b2,
abstract = {{<p>Starch nanoparticles (SNPs) are a promising choice for the strategic development of new renewable and biodegradable nanomaterials for novel biomedical and pharmaceutical applications when loaded with antibiotics or with anticancer agents as target drug delivery systems. The final properties of the SNPs are strongly influenced by the synthesis method and conditions being a controlled and monodispersed size crucial for these applications. The aim of this work was to synthesize controlled size SNPs through nanoprecipitation and microemulsion methods by modifying main operating parameters regarding the effect of amylose and amylopectin ratio in maize starches. SNPs were characterized by size and shape. SNPs from 59 to 118 nm were obtained by the nanoprecipitation method, registering the higer values when surfactant was added to the aqueous phase. Microemulsion method led to 35−147 nm sizes observing a higher particle formation capacity. The composition of the maize used influenced the final particle size and shape.</p>}},
author = {{Gutiérrez, G. and Morán, D. and Marefati, A. and Purhagen, J. and Rayner, M. and Matos, M.}},
issn = {{0144-8617}},
keywords = {{Absolute ethanol (PubChem CID: 702); CTAB (PubChem CID: 5974); High amylose; Microemulsion; Nanoprecipitation; Size control; Sodium hydroxide (PubChem CID: 14798); Span 60 (PubChem CID: 3793749); Starch nanoparticles; Tween 20 (PubChem CID: 443314); Urea (PubChem CID: 1176); Waxy}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Carbohydrate Polymers}},
title = {{Synthesis of controlled size starch nanoparticles (SNPs)}},
url = {{http://dx.doi.org/10.1016/j.carbpol.2020.116938}},
doi = {{10.1016/j.carbpol.2020.116938}},
volume = {{250}},
year = {{2020}},
}