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Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk : Results from the EPIC cohort study

Sanikini, Harinakshi; Dik, Vincent K.; Siersema, Peter D.; Bhoo-Pathy, Nirmala; Uiterwaal, Cuno S P M; Peeters, Petra H M; González, Carlos A.; Zamora-Ros, Raul; Overvad, Kim and Tjønneland, Anne, et al. (2015) In International Journal of Cancer 136(6). p.720-730
Abstract

Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee and tea consumption were assessed by dietary questionnaires at baseline. Adjusted hazard ratios (HRs) were calculated using Cox regression models. During 11.6 years of follow up, 683 gastric adenocarcinoma cases were identified among 477,312 participants. We found no significant association between overall gastric cancer risk and consumption of... (More)

Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee and tea consumption were assessed by dietary questionnaires at baseline. Adjusted hazard ratios (HRs) were calculated using Cox regression models. During 11.6 years of follow up, 683 gastric adenocarcinoma cases were identified among 477,312 participants. We found no significant association between overall gastric cancer risk and consumption of total coffee (HR 1.09, 95%-confidence intervals [CI]: 0.84-1.43; quartile 4 vs. non/quartile 1), caffeinated coffee (HR 1.14, 95%-CI: 0.82-1.59; quartile 4 vs. non/quartile 1), decaffeinated coffee (HR 1.07, 95%-CI: 0.75-1.53; tertile 3 vs. non/tertile 1) and tea (HR 0.81, 95%-CI: 0.59-1.09; quartile 4 vs. non/quartile 1). When stratified by anatomical site, we observed a significant positive association between gastric cardia cancer risk and total coffee consumption per increment of 100 mL/day (HR 1.06, 95%-CI: 1.03-1.11). Similarly, a significant positive association was observed between gastric cardia cancer risk and caffeinated coffee consumption (HR 1.98, 95%-CI: 1.16-3.36, p-trend=0.06; quartile 3 vs. non/quartile 1) and per increment of 100 mL/day (HR 1.09, 95%-CI: 1.04-1.14). In conclusion, consumption of total, caffeinated and decaffeinated coffee and tea is not associated with overall gastric cancer risk. However, total and caffeinated coffee consumption may be associated with an increased risk of gastric cardia cancer. Further prospective studies are needed to rule out chance or confounding.

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keywords
Caffeinated coffee, Coffee, Decaffeinated coffee, European prospective investigation into cancer and nutrition, Gastric cancer, Tea
in
International Journal of Cancer
volume
136
issue
6
pages
720 - 730
publisher
John Wiley & Sons
external identifiers
  • scopus:84961289846
ISSN
0020-7136
DOI
10.1002/ijc.29223
language
English
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yes
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7fc75fc8-4ccb-4c0b-818f-a8ad7c5af758
date added to LUP
2016-05-18 17:24:56
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2017-03-22 08:48:35
@article{7fc75fc8-4ccb-4c0b-818f-a8ad7c5af758,
  abstract     = {<p>Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee and tea consumption were assessed by dietary questionnaires at baseline. Adjusted hazard ratios (HRs) were calculated using Cox regression models. During 11.6 years of follow up, 683 gastric adenocarcinoma cases were identified among 477,312 participants. We found no significant association between overall gastric cancer risk and consumption of total coffee (HR 1.09, 95%-confidence intervals [CI]: 0.84-1.43; quartile 4 vs. non/quartile 1), caffeinated coffee (HR 1.14, 95%-CI: 0.82-1.59; quartile 4 vs. non/quartile 1), decaffeinated coffee (HR 1.07, 95%-CI: 0.75-1.53; tertile 3 vs. non/tertile 1) and tea (HR 0.81, 95%-CI: 0.59-1.09; quartile 4 vs. non/quartile 1). When stratified by anatomical site, we observed a significant positive association between gastric cardia cancer risk and total coffee consumption per increment of 100 mL/day (HR 1.06, 95%-CI: 1.03-1.11). Similarly, a significant positive association was observed between gastric cardia cancer risk and caffeinated coffee consumption (HR 1.98, 95%-CI: 1.16-3.36, p-trend=0.06; quartile 3 vs. non/quartile 1) and per increment of 100 mL/day (HR 1.09, 95%-CI: 1.04-1.14). In conclusion, consumption of total, caffeinated and decaffeinated coffee and tea is not associated with overall gastric cancer risk. However, total and caffeinated coffee consumption may be associated with an increased risk of gastric cardia cancer. Further prospective studies are needed to rule out chance or confounding.</p>},
  author       = {Sanikini, Harinakshi and Dik, Vincent K. and Siersema, Peter D. and Bhoo-Pathy, Nirmala and Uiterwaal, Cuno S P M and Peeters, Petra H M and González, Carlos A. and Zamora-Ros, Raul and Overvad, Kim and Tjønneland, Anne and Roswall, Nina and Boutron-Ruault, Marie Christine and Fagherazzi, Guy and Racine, Antoine and Kühn, Tilman and Katzke, Verena and Boeing, Heiner and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Lagiou, Pagona and Palli, Domenico and Grioni, Sara and Vineis, Paolo and Tumino, Rosario and Panico, Salvatore and Weiderpass, Elisabete and Skeie, Guri and Braaten, Tonje and Huerta, José Maŕa and Sánchez-Cantalejo, Emilio and Barricarte, Aurelio and Sonestedt, Emily and Wallstrom, Peter and Nilsson, Lena Maria and Johansson, Ingegerd and Bradbury, Kathryn E. and Khaw, Kay Tee and Wareham, Nick and Huybrechts, Inge and Freisling, Heinz and Cross, Amanda J. and Riboli, Elio and Bueno-de-Mesquita, H. B.},
  issn         = {0020-7136},
  keyword      = {Caffeinated coffee,Coffee,Decaffeinated coffee,European prospective investigation into cancer and nutrition,Gastric cancer,Tea},
  language     = {eng},
  month        = {03},
  number       = {6},
  pages        = {720--730},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk : Results from the EPIC cohort study},
  url          = {http://dx.doi.org/10.1002/ijc.29223},
  volume       = {136},
  year         = {2015},
}