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Factors affecting recall rate and false positive fraction in breast cancer screening with breast tomosynthesis - A statistical approach.

Rosso, Aldana LU ; Lång, Kristina LU ; Petersson, Ingemar LU and Zackrisson, Sophia LU (2015) In Breast 24(5). p.680-686
Abstract
In this study, we investigate which factors affect the false positive fraction (FPF) for digital breast tomosynthesis (DBT) compared to digital mammography (DM) in a screening population by using classification and regression trees (C&RT) and binary marginal generalized linear models. The data was obtained from the Malmö Breast Tomosynthesis Screening Trial, which aimed to compare the performance of DBT to DM in breast cancer screening. By using data from the first half of the study population (7500 women), a tree with the recall probability for different groups was calculated. The effect of age and breast density on the FPF was estimated using a binary marginal generalized linear model. Our results show that breast density and breast... (More)
In this study, we investigate which factors affect the false positive fraction (FPF) for digital breast tomosynthesis (DBT) compared to digital mammography (DM) in a screening population by using classification and regression trees (C&RT) and binary marginal generalized linear models. The data was obtained from the Malmö Breast Tomosynthesis Screening Trial, which aimed to compare the performance of DBT to DM in breast cancer screening. By using data from the first half of the study population (7500 women), a tree with the recall probability for different groups was calculated. The effect of age and breast density on the FPF was estimated using a binary marginal generalized linear model. Our results show that breast density and breast cancer were the main factors influencing recall. The FPF is mainly affected by breast density and increases with breast density for DBT and DM. In conclusion, the results obtained with C&RT are easy to interpret and similar to those obtained using binary marginal generalized linear models. The FPF is approximately 40% higher for DBT compared to DM for all breast density categories. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Breast
volume
24
issue
5
pages
680 - 686
publisher
Churchill Livingstone
external identifiers
  • pmid:26365133
  • wos:000362378800028
  • scopus:84952637591
ISSN
1532-3080
DOI
10.1016/j.breast.2015.08.007
language
English
LU publication?
yes
id
b3a677bd-8581-4a92-b88b-4e084750a791 (old id 8042409)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26365133?dopt=Abstract
date added to LUP
2015-10-04 13:36:37
date last changed
2017-01-01 03:46:52
@article{b3a677bd-8581-4a92-b88b-4e084750a791,
  abstract     = {In this study, we investigate which factors affect the false positive fraction (FPF) for digital breast tomosynthesis (DBT) compared to digital mammography (DM) in a screening population by using classification and regression trees (C&RT) and binary marginal generalized linear models. The data was obtained from the Malmö Breast Tomosynthesis Screening Trial, which aimed to compare the performance of DBT to DM in breast cancer screening. By using data from the first half of the study population (7500 women), a tree with the recall probability for different groups was calculated. The effect of age and breast density on the FPF was estimated using a binary marginal generalized linear model. Our results show that breast density and breast cancer were the main factors influencing recall. The FPF is mainly affected by breast density and increases with breast density for DBT and DM. In conclusion, the results obtained with C&RT are easy to interpret and similar to those obtained using binary marginal generalized linear models. The FPF is approximately 40% higher for DBT compared to DM for all breast density categories.},
  author       = {Rosso, Aldana and Lång, Kristina and Petersson, Ingemar and Zackrisson, Sophia},
  issn         = {1532-3080},
  language     = {eng},
  number       = {5},
  pages        = {680--686},
  publisher    = {Churchill Livingstone},
  series       = {Breast},
  title        = {Factors affecting recall rate and false positive fraction in breast cancer screening with breast tomosynthesis - A statistical approach.},
  url          = {http://dx.doi.org/10.1016/j.breast.2015.08.007},
  volume       = {24},
  year         = {2015},
}