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Myocardium at risk can be determined by ex vivo T2-weighted magnetic resonance imaging even in the presence of gadolinium: comparison to myocardial perfusion single photon emission computed tomography.

Ubachs, Joey LU ; Engblom, Henrik LU ; Koul, Sasha LU ; Kanski, Mikael LU ; Gilje, Patrik LU ; vanderPals, Jesper LU ; Carlsson, Marcus LU ; Erlinge, David LU and Arheden, Håkan LU (2013) In European Heart Journal-Cardiovascular Imaging 14(3). p.261-268
Abstract
AIMS: Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by CMR. We aimed to test the ability of ex vivo T2-weighted imaging to assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference and to investigate whether MaR could be assessed by ex vivo T2-weighted imaging after injection of gadolinium.



Materials and... (More)
AIMS: Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by CMR. We aimed to test the ability of ex vivo T2-weighted imaging to assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference and to investigate whether MaR could be assessed by ex vivo T2-weighted imaging after injection of gadolinium.



Materials and methods

In 18 domestic pigs, the left anterior descending artery was occluded for either 30 or 40 min, followed by 4 h of reperfusion. After explantation of the hearts, myocardial perfusion SPECT and T2-weighted imaging were performed for determination of MaR, either with or without gadolinium. Infarct size was determined by T1-weighted imaging and by triphenyl tetrazolium chloride (TTC) staining. RESULTS: T2-weighted imaging agreed with myocardial perfusion SPECT, both with and without gadolinium (r(2)= 0.70, P < 0.01) with a bias of 2.6 ± 5.1% (P = 0.04). Infarct size was 15.4 ± 5.3 and 22.1 ± 5.6% with TTC and T1-weighted imaging, respectively (P = 0.008) in nine pigs who had both infarct measures.



CONCLUSION: T2-weighted CMR imaging can be used to determine MaR in an ex vivo experimental model, both with and without the presence of gadolinium. Thus, CMR alone can be used to assess myocardial salvage in experimental studies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Heart Journal-Cardiovascular Imaging
volume
14
issue
3
pages
261 - 268
publisher
Oxford University Press
external identifiers
  • wos:000315050200016
  • pmid:22822155
  • scopus:84874293079
ISSN
2047-2412
DOI
10.1093/ehjci/jes142
language
English
LU publication?
yes
id
82049ead-26e7-4140-b36b-0a71b4a8013a (old id 2966767)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22822155?dopt=Abstract
date added to LUP
2012-08-09 21:19:32
date last changed
2019-05-14 03:22:24
@article{82049ead-26e7-4140-b36b-0a71b4a8013a,
  abstract     = {AIMS: Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by CMR. We aimed to test the ability of ex vivo T2-weighted imaging to assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference and to investigate whether MaR could be assessed by ex vivo T2-weighted imaging after injection of gadolinium.<br/><br>
<br/><br>
Materials and methods<br/><br>
In 18 domestic pigs, the left anterior descending artery was occluded for either 30 or 40 min, followed by 4 h of reperfusion. After explantation of the hearts, myocardial perfusion SPECT and T2-weighted imaging were performed for determination of MaR, either with or without gadolinium. Infarct size was determined by T1-weighted imaging and by triphenyl tetrazolium chloride (TTC) staining. RESULTS: T2-weighted imaging agreed with myocardial perfusion SPECT, both with and without gadolinium (r(2)= 0.70, P &lt; 0.01) with a bias of 2.6 ± 5.1% (P = 0.04). Infarct size was 15.4 ± 5.3 and 22.1 ± 5.6% with TTC and T1-weighted imaging, respectively (P = 0.008) in nine pigs who had both infarct measures. <br/><br>
<br/><br>
CONCLUSION: T2-weighted CMR imaging can be used to determine MaR in an ex vivo experimental model, both with and without the presence of gadolinium. Thus, CMR alone can be used to assess myocardial salvage in experimental studies.},
  author       = {Ubachs, Joey and Engblom, Henrik and Koul, Sasha and Kanski, Mikael and Gilje, Patrik and vanderPals, Jesper and Carlsson, Marcus and Erlinge, David and Arheden, Håkan},
  issn         = {2047-2412},
  language     = {eng},
  number       = {3},
  pages        = {261--268},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal-Cardiovascular Imaging},
  title        = {Myocardium at risk can be determined by ex vivo T2-weighted magnetic resonance imaging even in the presence of gadolinium: comparison to myocardial perfusion single photon emission computed tomography.},
  url          = {http://dx.doi.org/10.1093/ehjci/jes142},
  volume       = {14},
  year         = {2013},
}