Myocardium at risk can be determined by ex vivo T2-weighted magnetic resonance imaging even in the presence of gadolinium: comparison to myocardial perfusion single photon emission computed tomography.
Ubachs, Joey LU ; Engblom, Henrik LU ; Koul, Sasha LU ; Kanski, Mikael LU ; Gilje, Patrik LU ; vanderPals, Jesper LU ; Carlsson, Marcus LU ; Erlinge, David LU
and Arheden, Håkan
LU
(2013)
In European Heart Journal-Cardiovascular Imaging
14(3).
p.261-268
- Abstract
- AIMS: Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by CMR. We aimed to test the ability of ex vivo T2-weighted imaging to assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference and to investigate whether MaR could be assessed by ex vivo T2-weighted imaging after injection of gadolinium.
Materials and... (More) - AIMS: Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by CMR. We aimed to test the ability of ex vivo T2-weighted imaging to assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference and to investigate whether MaR could be assessed by ex vivo T2-weighted imaging after injection of gadolinium.
Materials and methods
In 18 domestic pigs, the left anterior descending artery was occluded for either 30 or 40 min, followed by 4 h of reperfusion. After explantation of the hearts, myocardial perfusion SPECT and T2-weighted imaging were performed for determination of MaR, either with or without gadolinium. Infarct size was determined by T1-weighted imaging and by triphenyl tetrazolium chloride (TTC) staining. RESULTS: T2-weighted imaging agreed with myocardial perfusion SPECT, both with and without gadolinium (r(2)= 0.70, P < 0.01) with a bias of 2.6 ± 5.1% (P = 0.04). Infarct size was 15.4 ± 5.3 and 22.1 ± 5.6% with TTC and T1-weighted imaging, respectively (P = 0.008) in nine pigs who had both infarct measures.
CONCLUSION: T2-weighted CMR imaging can be used to determine MaR in an ex vivo experimental model, both with and without the presence of gadolinium. Thus, CMR alone can be used to assess myocardial salvage in experimental studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2966767
- author
- Ubachs, Joey
LU
; Engblom, Henrik
LU
; Koul, Sasha
LU
; Kanski, Mikael
LU
; Gilje, Patrik
LU
; vanderPals, Jesper
LU
; Carlsson, Marcus
LU
; Erlinge, David
LU
and Arheden, Håkan
LU
- organization
- publishing date
- 2013-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Heart Journal-Cardiovascular Imaging
- volume
- 14
- issue
- 3
- pages
- 261 - 268
- publisher
- Oxford University Press
- external identifiers
-
- wos:000315050200016
- pmid:22822155
- scopus:84874293079
- pmid:22822155
- ISSN
- 2047-2412
- DOI
- 10.1093/ehjci/jes142
- language
- English
- LU publication?
- yes
- id
- 82049ead-26e7-4140-b36b-0a71b4a8013a (old id 2966767)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22822155?dopt=Abstract
- date added to LUP
- 2016-04-04 08:47:23
- date last changed
- 2022-03-23 02:58:28
@article{82049ead-26e7-4140-b36b-0a71b4a8013a,
abstract = {{AIMS: Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by CMR. We aimed to test the ability of ex vivo T2-weighted imaging to assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference and to investigate whether MaR could be assessed by ex vivo T2-weighted imaging after injection of gadolinium.<br/><br>
<br/><br>
Materials and methods<br/><br>
In 18 domestic pigs, the left anterior descending artery was occluded for either 30 or 40 min, followed by 4 h of reperfusion. After explantation of the hearts, myocardial perfusion SPECT and T2-weighted imaging were performed for determination of MaR, either with or without gadolinium. Infarct size was determined by T1-weighted imaging and by triphenyl tetrazolium chloride (TTC) staining. RESULTS: T2-weighted imaging agreed with myocardial perfusion SPECT, both with and without gadolinium (r(2)= 0.70, P < 0.01) with a bias of 2.6 ± 5.1% (P = 0.04). Infarct size was 15.4 ± 5.3 and 22.1 ± 5.6% with TTC and T1-weighted imaging, respectively (P = 0.008) in nine pigs who had both infarct measures. <br/><br>
<br/><br>
CONCLUSION: T2-weighted CMR imaging can be used to determine MaR in an ex vivo experimental model, both with and without the presence of gadolinium. Thus, CMR alone can be used to assess myocardial salvage in experimental studies.}},
author = {{Ubachs, Joey and Engblom, Henrik and Koul, Sasha and Kanski, Mikael and Gilje, Patrik and vanderPals, Jesper and Carlsson, Marcus and Erlinge, David and Arheden, Håkan}},
issn = {{2047-2412}},
language = {{eng}},
number = {{3}},
pages = {{261--268}},
publisher = {{Oxford University Press}},
series = {{European Heart Journal-Cardiovascular Imaging}},
title = {{Myocardium at risk can be determined by ex vivo T2-weighted magnetic resonance imaging even in the presence of gadolinium: comparison to myocardial perfusion single photon emission computed tomography.}},
url = {{http://dx.doi.org/10.1093/ehjci/jes142}},
doi = {{10.1093/ehjci/jes142}},
volume = {{14}},
year = {{2013}},
}